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(E)-CROTONALDEHYDE

6.1 - Poison Inhalation Hazard 3 - Flammable liquid
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The Chemical Identifier fields include common identification numbers, the NFPA diamond, U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 123-73-9   ((E)-CROTONALDEHYDE)
DOT Hazard Label USCG CHRIS Code
  • Poison Inhalation Hazard
  • Flammable Liquid
none
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
Diamond Hazard Value Description
3
4 2
Blue Health 4 Can be lethal.
Red Flammability 3 Can be ignited under almost all ambient temperature conditions.
Yellow Instability 2 Readily undergoes violent chemical changes at elevated temperatures and pressures.
White Special
Note: NFPA ratings shown are for crotonaldehyde, CAS number 4170-30-3.
(NFPA, 2010)
General Description
Water-white to straw-colored liquid with a pungent, suffocating odor. Used as a chemical intermediate in a variety of industrial processes (surfactants, textiles, paper, fuels, insecticides, leather tanning, etc.). Used in chemical warfare. (EPA, 1998)

The Hazard fields include special hazard alerts, air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
  • Highly Flammable
  • Polymerizable
Air & Water Reactions
Highly flammable.
Fire Hazard
Vapors form explosive mixtures in air or in sewers. Hazardous peroxides and acids emitted when heated to decomposition. Avoid nitric acid. Unstable, avoid oxygen, heat, elevated pressures. Hazardous polymerization may occur. Avoid contact with alkaline materials such as caustic ammonia or amines, or at elevated temperatures. (EPA, 1998)
Health Hazard
Although slightly less toxic, crotonaldehyde is similar chemically and toxicologically to acrolein, which is rated as extremely toxic. Toxic concentrations for human inhalation have been reported at 12 mg/m3/10 minutes. Irritant dose to human eye is 45 ppm. As with acrolein, vapor exposures cause severe and painful eye irritation, damage to cornea, lacrimation (tearing), irritation of nasal membranes, pulmonary edema (filling of lungs with fluid) and gastrointestinal distress when ingested. (EPA, 1998)
Reactivity Profile
(E)-CROTONALDEHYDE is an aldehyde. It can react violently with strong oxidizing reagents, e.g., reaction with conc. nitric acid leads to instantaneous ignition [Andrussow, L., Chim. Ind. (Paris), 1961, 86, p. 542]. In contact with strong acids or bases it will undergo an exothermic condensation reaction. Reaction with 1,3-butadiene is particularly violent [Greenlee, K. W., Chem. Eng. News, 1948, 26, p. 1985]. Crotonaldehyde may rapidly polymerize with ethyl acetoacetate (Soriano, D.S. et al. 1988. Journal of Chemical Education 65:637.).
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below. More info about absorbents, including situations to watch out for...

  • Cellulose-Based Absorbents
  • Mineral-Based & Clay-Based Absorbents
  • Dirt/Earth

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 131P [Flammable Liquids - Toxic]:

As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1143 datasheet.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Firefighting
All exposed skin surfaces should be covered. Wear protective clothing including self-contained breathing apparatus, coat, pants, gloves, boots, and bands around arms, wrists, legs, and waist. Massive or advanced fires should be fought from a safe distance or protected location. Isolate area for one-half mile in all directions if tank car or truck involved in fire.

Use dry chemical, foam, or carbon dioxide; water may be ineffective but should be used to keep fire-exposed containers cool. If leak or spill has not ignited, use water spray to disperse vapors. Water spray may be used to flush spills away from exposures. (EPA, 1998)
Non-Fire Response
Remove all ignition sources and ventilate area of spill. No flares, smoking, or flames in hazard area. Do not touch spilled material; stop leak if you can do so without risk. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
Tychem® Fabric Legend
QS = Tychem 2000 SFR
QC = Tychem 2000
SL = Tychem 4000
C3 = Tychem 5000
TF = Tychem 6000
TP = Tychem 6000 FR
BR = Tychem 9000
RC = Tychem RESPONDER® CSM
TK = Tychem 10000
RF = Tychem 10000 FR
Testing Details
The fabric permeation data was generated for DuPont by independent testing laboratories using ASTM F739, EN369, EN 374-3, EN ISO 6529 (method A and B) or ASTM D6978 test methods. Normalized breakthrough times (the time at which the permeation rate is equal to 0.1 µg/cm2/min) reported in minutes. All liquid chemicals have been tested between approximately 20°C and 27°C unless otherwise stated. A different temperature may have significant influence on the breakthrough time; permeation rates typically increase with temperature. All chemicals have been tested at a concentration of greater than 95% unless otherwise stated. Unless otherwise stated, permeation was measured for single chemicals. The permeation characteristics of mixtures can deviate considerably from the permeation behavior of the individual chemicals. Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50% relative humidity per military standard MIL-STD-282.
Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP BR RC TK RF
trans-Crotonaldehyde (>95%) 123-73-9 Liquid 34 >480 >480 >480 >480
> indicates greater than.
A blank cell indicates the fabric has not been tested. The fabric may or may not offer barrier.

Special Warnings from DuPont

  1. Serged and bound seams are degraded by some hazardous liquid chemicals, such as strong acids, and should not be worn when these chemicals are present.
  2. CAUTION: This information is based upon technical data that DuPont believes to be reliable. It is subject to revision as additional knowledge and experience are gained. DuPont makes no guarantee of results and assumes no obligation or liability...
    ... in connection with this information. It is the user's responsibility to determine the level of toxicity and the proper personal protective equipment needed. The information set forth herein reflects laboratory performance of fabrics, not complete garments, under controlled conditions. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk. Anyone intending to use this information should first verify that the garment selected is suitable for the intended use. In many cases, seams and closures have shorter breakthrough times and higher permeation rates than the fabric. Please contact DuPont for specific data. If fabric becomes torn, abraded or punctured, or if seams or closures fail, or if attached gloves, visors, etc. are damaged, end user should discontinue use of garment to avoid potential exposure to chemical. Since conditions of use are outside our control, we make no warranties, express or implied, including, without limitation, no warranties of merchantability or fitness for a particular use and assume no liability in connection with any use of this information. This information is not intended as a license to operate under or a recommendation to infringe any patent or technical information of DuPont or others covering any material or its use.

(DuPont, 2018)

First Aid
Warning: Crotonaldehyde, (E)- is an extreme eye, respiratory, and skin irritant and can cause corneal damage. Caution is advised.

Signs and Symptoms of Crotonaldehyde, (E)- Exposure: Signs and symptoms of acute exposure to crotonaldehyde, (E)- may include irritation of the eyes, skin, mucous membranes, nose, throat and upper respiratory tract. Delayed onset of pulmonary edema is possible following inhalation. Corneal damage may occur as may allergic contact dermatitis. Seizures may also be observed.

Emergency Life-Support Procedures: Acute exposure to crotonaldehyde, (E)- may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contami-nation. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to crotonaldehyde, (E)-.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to crotonaldehyde, (E)-.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. DO NOT induce vomiting.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C4H6O
Flash Point: 55.4 ° F (EPA, 1998)
Lower Explosive Limit (LEL): 2.1 % (EPA, 1998)
Upper Explosive Limit (UEL): 15.5 % (EPA, 1998)
Autoignition Temperature: data unavailable
Melting Point: -101 ° F (EPA, 1998)
Vapor Pressure: 19 mm Hg at 68 ° F (EPA, 1998)
Vapor Density (Relative to Air): 2.41 (EPA, 1998)
Specific Gravity: 0.853 at 68 ° F (EPA, 1998)
Boiling Point: 219.2 ° F at 760 mm Hg (EPA, 1998)
Molecular Weight: 70.1 (EPA, 1998)
Water Solubility: data unavailable
Ionization Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

Final AEGLs for trans-Crotonaldehyde (123-73-9)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes 0.19 ppm 27 ppm 44 ppm
30 minutes 0.19 ppm 8.9 ppm 27 ppm
60 minutes 0.19 ppm 4.4 ppm 14 ppm
4 hours 0.19 ppm 1.1 ppm 2.6 ppm
8 hours 0.19 ppm 0.56 ppm 1.5 ppm
(NAC/NRC, 2017)

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Crotonaldehyde, trans- (123-73-9) 0.19 ppm 4.4 ppm 14 ppm
(DOE, 2016)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
2-Butenal, (e)- 123-73-9 1000 pounds 100 pounds 100 pounds U053 20000 pounds
Crotonaldehyde, (E)- 123-73-9 1000 pounds 100 pounds 100 pounds U053 20000 pounds

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

RELEASE THEFT SABOTAGE
Chemical of Interest CAS Number Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
Crotonaldehyde, (E)-; [2-Butenal], (E)-] 123-73-9 1.00 % 10000 pounds flammable

(DHS, 2007)

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • BETA-METHYL ACROLEIN
  • 2-BUTENAL(TRANS)
  • 2-BUTENAL, (E)-
  • 2-BUTENAL,(E)-
  • CROTENALDEHYDE
  • CROTONAL
  • CROTONALDEHYDE
  • CROTONALDEHYDE, (E)-
  • CROTONALDEHYDE,(E)-
  • CROTONIC ALDEHYDE
  • (E)-2-BUTENAL
  • 2(E)-BUTENAL
  • (E)-CROTONALDEHYDE
  • E-2-BUTENAL
  • NCI-C56279
  • PROPYLENE ALDEHYDE
  • TOPANEL
  • TOPANEL CA
  • TRANS-2-BUTEN-1-AL
  • TRANS-2-BUTENAL
  • TRANS-CROTONAL
  • TRANS-CROTONALDEHYDE

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