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HEXAMETHYLPHOSPHORAMIDE

6.1 - Poison
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The Chemical Identifier fields include common identification numbers, the NFPA diamond, U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 680-31-9   (HEXAMETHYLPHOSPHORAMIDE)
DOT Hazard Label USCG CHRIS Code
  • Poison
none
NIOSH Pocket Guide International Chem Safety Card
Hexamethyl phosphoramideexternal link
NFPA 704
data unavailable
General Description
PHYSICAL DESCRIPTION: Clear colorless to light amber liquid with a spicy odor. (NTP, 1992)

The Hazard fields include special hazard alerts, air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
Water soluble.
Fire Hazard
This chemical is combustible. (NTP, 1992)
Health Hazard
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact

Symptoms: Irritation eyes, skin, respiratory system; dyspnea (breathing difficulty); abdominal pain; [potential occupational carcinogen]

Target Organs: Eyes, skin, respiratory system, central nervous system, gastrointestinal tract (NIOSH, 2016)
Reactivity Profile
HEXAMETHYLPHOSPHORAMIDE may react with strong oxidizing agents and strong acids (NTP, 1992). Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

No information available.

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Firefighting
Fires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Non-Fire Response
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)
Protective Clothing
Skin: Wear appropriate personal protective clothing to prevent skin contact.

Eyes: Wear appropriate eye protection to prevent eye contact.

Wash skin: The worker should immediately wash the skin when it becomes contaminated.

Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: No recommendation is made specifying the need for the worker to change clothing after the work shift.

Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C6H18N3OP
Flash Point: 222 ° F (NTP, 1992)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: 41 to 45 ° F (NTP, 1992)
Vapor Pressure: 0.07 mm Hg at 77 ° F (NTP, 1992)
Vapor Density (Relative to Air): 6.18 (NTP, 1992)
Specific Gravity: 1.024 at 77 ° F (NTP, 1992)
Boiling Point: 451 ° F at 760 mm Hg (NTP, 1992)
Molecular Weight: 179.2 (NTP, 1992)
Water Solubility: greater than or equal to 100 mg/mL at 64┬░ F (NTP, 1992)
Ionization Potential: data unavailable
IDLH: A potential occupational carcinogen. (NIOSH, 2016)

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Hexamethylphosphoramide (680-31-9) 0.34 ppm 3.7 ppm 17 ppm
(DOE, 2016)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Hexamethylphosphoramide 680-31-9 1 pound 313

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • EASTMAN INHIBITOR HPT
  • ENT 50,882
  • ENT 50882
  • HEMPA
  • HEXAMETAPOL
  • HEXAMETHYL PHOSPHORAMIDE
  • HEXAMETHYLORTHOPHOSPHORIC TRIAMIDE
  • HEXAMETHYLPHOSPHORAMIDE
  • HEXAMETHYLPHOSPHORIC ACID TRIAMIDE
  • HEXAMETHYLPHOSPHORIC TRIAMIDE
  • HEXAMETHYLPHOSPHOROTRIAMIDE
  • HEXAMETHYLPHOSPHOTRIAMIDE
  • HEXAMETHYLTRIAMIDOPHOSPHATE
  • HMPA
  • HMPT
  • HMPTA
  • HPT
  • N,N',N''-HEXAMETHYLPHOSPHORAMIDE
  • N,N,N,N,N,N-HEXAMETHYLPHOSPHORIC TRIAMIDE
  • PHOSPHORIC ACID HEXAMETHYLTRIAMIDE
  • PHOSPHORIC HEXAMETHYLTRIAMIDE
  • PHOSPHORIC TRIS(DIMETHYLAMIDE)
  • PHOSPHORYL HEXAMETHYLTRIAMIDE
  • TRIS(DIMETHYLAMINO)PHOSPHINE OXIDE
  • TRIS(DIMETHYLAMINO)PHOSPHORUS OXIDE

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