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CHLORAMBUCIL

6.1 - Poison
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The Chemical Identifier fields include common identification numbers, the NFPA diamond U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 305-03-3
DOT Hazard Label USCG CHRIS Code
  • Poison
none
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
data unavailable
General Description
PHYSICAL DESCRIPTION: White to pale beige crystalline or granular powder with a slight odor. Melting point 65-69°C.

The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
Insoluble in water.
Fire Hazard
Literature sources indicate that this chemical is nonflammable. (NTP, 1992)
Health Hazard
SYMPTOMS: Symptoms of exposure to this compound include leukemia, dyspnea, cough, interstitial fibrosis and menstrual cycle changes or disorders. It may cause keratitis epithelialis in association with exfoliative dermatitis and reversible pseudotumor cerebri with papilledema. It may also cause vomiting, lethargy and unconsciousness with grand mal seizures. Other symptoms include convulsions, infertility, reversible and permanent sterility, lymphopenia, neutropenia, bone marrow suppression, gastrointestinal disturbances such as nausea, diarrhea and oral ulceration, hepatotoxicity, jaundice, drug fever, skin hypersensitivity, peripheral neuropathy, sterile cystitis, fibrosis, vasculitis and depletion of primordial follicles, skin rash, bleeding, unusual lumps, agitated behavior and ataxia. It may cause hyperuricemia, which may lead to acute renal failure, reversible pancytopenia, sideroblastic anemia and myeloblastic leukemia. Exposure may cause erythroleukemia, reticulum-cell sarcoma, lymphosarcoma, myelosuppression, viral, fungal and bacterial infections, chromosomal damage and oligospermia, azoospermia and disappearance of testicular germinal cells in males. It may cause irreversible bone marrow depression, central nervous excitation and jerky movements. It may also cause thrombocytopenia, leucopenia and hemorrhage of the skin and mucous membranes. Other symptoms of exposure include coma, irritation to the skin and mucous membranes, lymphocytopenia, cutaneous pigmentation, adrenal cortical insufficiency and neurotoxicity. It may cause amenorrhea and dermatitis. When administered to a pregnant woman, the offspring may develop unilateral renal agenesis. It may be injurious to the developing retina.

ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin and mucous membranes. It is rapidly and completely absorbed from the gastrointestinal tract. When heated to decomposition it emits toxic fumes of chlorine and nitrogen oxides. (NTP, 1992)
Reactivity Profile
CHLORAMBUCIL is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds (NTP, 1992).
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...

  • Mineral-Based & Clay-Based Absorbents

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Firefighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
Non-Fire Response
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)
Protective Clothing
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds The information in CAMEO Chemicals comes from a variety of data sources.

Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circumstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.
Chemical Formula:
  • C14H19Cl2NO2
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: 147 to 151°F (NTP, 1992)
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
Molecular Weight: 304.23 (NTP, 1992)
Water Solubility: less than 0.1 mg/mL at 72°F (NTP, 1992)
Ionization Energy/Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

No PAC information available.

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Chlorambucil 305-03-3 10 pounds U035

(EPA List of Lists, 2022)

CISA Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • AMBOCHLORIN
  • AMBOCLORIN
  • BENZENEBUTANOIC ACID, 4-(BIS(2-CHLOROETHYL)AMINO)-
  • 4-(BIS(2-CHLOROETHYL)AMINO)BENZENEBUTANOIC ACID
  • BUTANOIC ACID, 4-(BIS(2-CHLOROETHYL)AMINO)BENZENE-
  • BUTYRIC ACID, 4-(P-BIS(2-CHLOROETHYL)AMINOPHENYL)-
  • BUTYRIC ACID, 4-[P-[BIS(2-CHLOROETHYL)AMINO]PHENYL]-
  • CB 1348
  • CHLORAMBUCIL
  • CHLORAMINOPHEN
  • CHLORAMINOPHENE
  • CHLORBUTIN
  • CHLOROAMBUCIL
  • CHLOROBUTIN
  • CHLOROBUTINE
  • ECLORIL
  • ELCORIL
  • GAMMA-(P-BIS(2-CHLOROETHYL)AMINOPHENYL)BUTYRIC ACID
  • GAMMA-(P-DI(2-CHLOROETHYL)AMINOPHENYL)BUTYRIC ACID
  • GAMMA-[P-BIS(2-CHLOROETHYL)AMINOPHENYL]BUTYRIC ACID
  • GAMMA-[P-DI(2-CHLOROETHYL)AMINOPHENYL]BUTYRIC ACID
  • LEUKERAN
  • LEUKERSAN
  • LEUKORAN
  • LINFOLIZIN
  • LINFOLYSIN
  • LYMPHOLYSIN
  • N,N-DI-2-CHLOROETHYL-GAMMA-P-AMINOPHENYLBUTYRIC ACID
  • NCI-C03485
  • NSC 3088
  • NSC-3088
  • P-(N,N-DI-2-CHLOROETHYL)AMINOPHENYL BUTYRIC ACID
  • 4-(P-BIS(2-CHLOROETHYL)AMINOPHENYL)BUTYRIC ACID
  • 4-(P-BIS(BETA-CHLOROETHYL)AMINOPHENYL)BUTYRIC ACID
  • P-N,N-DI-(BETA-CHLOROETHYL)AMINOPHENYL BUTYRIC ACID
  • 4-[P-[BIS(2-CHLOROETHYL)AMINO]PHENYL]BUTYRIC ACID
  • PHENYLBUTYRIC ACID NITROGEN MUSTARD

Version 3.0.0