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PHENYTOIN

6.1 - Poison
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The Chemical Identifier fields include common identification numbers, the NFPA diamond, U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 57-41-0
DOT Hazard Label USCG CHRIS Code
  • Poison
none
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
data unavailable
General Description
PHYSICAL DESCRIPTION: Fine white or almost white crystalline powder. Odorless or almost odorless. Tasteless. (NTP, 1992)

The Hazard fields include special hazard alerts, air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazard
SYMPTOMS: Symptoms of exposure to this compound include ataxia, nystagmus, fever, agranulocytosis, lupus erythematosus, epidermal necrolysis, pseudolymphoma, slurred speech, mental confusion, dizziness, insomnia, transient nervousness, headache, dyskinesias, chorea, dystonia, asterixis, polyneuropathy, nausea, vomiting, constipation, rash (scarlatiniform or morbilliform), dermatitis (bullous, exfoliative or purpuric), thrombocytopenia, leukopenia, granulocytopenia, pancytopenia with or without bone marrow suppression, macrocytosis, megaloblastic anemia, coarsening of the facial features, gingival hyperplasia, toxic hepatitis, respiratory depression, Stevens-Johnson syndrome, coma and death. Other symptoms include central nervous system effects such as depression and motor restlessness, allergic reactions, gastric distress, hirsutism and blood dyscrasias. Exposure can cause liver damage, kidney damage, adenopathy, aplastic anemia, pulmonary changes, lymph gland enlargement, cardiac irregularities, peripheral nerve damage, tremor, drug psychosis, rigidity and convulsions. Exposure can also cause motor twitchings, decreased coordination, enlargement of the lips, hypertrichosis, Peyronie's Disease, periarteritis nodosa, immunoglobulin abnormalities, dysarthria, hyperreflexia, lethargy, hypertension and circulatory depression. It may cause tenderness of the gums, rickets, reduced bone density, osteomalacia, polyarthropathy, hyperglycemia, erythema multiforme, hypotension, blurred vision, unsteady gait, facial changes, thickening of the skull, thickening of the heel pad, eosinophilia, hemolytic anemia, myasthenia gravis, acquired hemophilia, leukemia, pulmonary function loss, decreased sexual potency and fertility, and cholestasis. It may also cause lymphadenopathy, lymphoma including Hodgkin's disease, hallucinations, excitation, cardiac arrhythmias, cerebellar-vestibular effects, behavioral changes, increased frequency of seizures, gastrointestinal symptoms, vertigo, mydriasis, hyperactivity, silliness, dullness, drowsiness, anorexia, inhibition of release of anti-diuretic hormone, glycosuria, hepatic necrosis, neutropenia and red-cell aplasia. Exposure may lead to blood changes, tumors of the skin and appendages, change in motor activity, degenerative brain changes and jaundice. It may also lead to diplopia, weakness of accommodation and convergence, stuporous mental state, mental disturbance, oscillopsia (very fine periodic dancing of the eyes vertically or horizontally), ophthalmoplegia and conjunctivitis. It can cause the eyes to be temporarily fixed in mid-position and can interfere with the vestibulo-ocular reflex arc.

ACUTE/CHRONIC HAZARDS: This compound is harmful by ingestion, inhalation and skin absorption. It may cause irritation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)
Reactivity Profile
PHENYTOIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). This chemical is incompatible with strong oxidizers and strong bases. (NTP, 1992)
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

No information available.

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Firefighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Non-Fire Response
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures and keep it away from oxidizing materials and bases. (NTP, 1992)
Protective Clothing
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C15H12N2O2
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: 563 to 568 ° F (NTP, 1992)
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
Molecular Weight: 252.27 (NTP, 1992)
Water Solubility: less than 0.1 mg/mL at 66┬░ F (NTP, 1992)
Ionization Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

No PAC information available.

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Phenytoin 57-41-0 313

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • ALEVIATIN
  • ANTISACER
  • AURANILE
  • CAUSOIN
  • CITRULLAMON
  • CITRULLIAMON
  • COMITAL
  • COMITOINA
  • CONVUL
  • DANTEN
  • DANTINAL
  • DANTOINAL
  • DANTOINAL KLINOS
  • DANTOINE
  • DENYL
  • DI-HYDAN
  • DI-LAN
  • DI-PHETINE
  • DIDAN-TDC-250
  • DIFENIN
  • DIFETOIN
  • DIFHYDAN
  • DIHYCON
  • DIHYDANTOIN
  • DILABID
  • DILANTIN
  • DILANTINE
  • DILLANTIN
  • DINTOIN
  • DINTOINA
  • DIPHANTOIN
  • DIPHEDAL
  • DIPHEDAN
  • DIPHENIN
  • DIPHENINE
  • DIPHENTOIN
  • DIPHENTYN
  • 5,5-DIPHENYL-2,4-IMIDAZOLIDINEDIONE
  • DIPHENYLAN
  • DIPHENYLHYDANTOIN
  • 5,5-DIPHENYLHYDANTOIN
  • 5,5-DIPHENYLIMIDAZOLIDIN-2,4-DIONE
  • DITOINATE
  • DPH
  • EKKO
  • EKKO CAPSULES
  • ELEPSINDON
  • ENKELFEL
  • EPAMIN
  • EPANUTIN
  • EPASMIR "5"
  • EPDANTOINE SIMPLE
  • EPELIN
  • EPIFENYL
  • EPIHYDAN
  • EPILAN
  • EPILAN-D
  • EPILANTIN
  • EPINAT
  • EPISED
  • EPTAL
  • EPTOIN
  • FENANTOIN
  • FENIDANTOIN "S"
  • FENITOINA
  • FENTOIN
  • FENYLEPSIN
  • FENYTOINE
  • GEROT-EPILAN-D
  • HIDAN
  • HIDANTAL
  • HIDANTILO
  • HIDANTINA
  • HIDANTINA SENOSIAN
  • HIDANTINA VITORIA
  • HIDANTOMIN
  • HINDATAL
  • HYDANTAL
  • HYDANTIN
  • HYDANTOIN
  • HYDANTOIN, 5,5-DIPHENYL-
  • HYDANTOINAL
  • HYDANTOL
  • ICTALIS SIMPLE
  • IDANTOIL
  • IDANTOIN
  • KESSODANTEN
  • LABOPAL
  • LEHYDAN
  • LEPITOIN
  • LEPSIN
  • MINETOIN
  • NCI-C55765
  • NEOS-HIDANTOINA
  • NEOSIDANTOINA
  • NOVANTOINA
  • OM HIDANTOINA SIMPLE
  • OM-HYDANTOINE
  • OXYLAN
  • PHANANTIN
  • PHANATINE
  • PHENATINE
  • PHENATOINE
  • PHENHYDAN
  • PHENITOIN
  • PHENTOIN
  • PHENYTOIN
  • PHENYTOINE
  • RITMENAL
  • SACERIL
  • SANEPIL
  • SILANTIN
  • SODANTOIN
  • SODANTON
  • SOLANTIN
  • SOLANTOIN
  • SOLANTYL
  • SYLANTOIC
  • TACOSAL
  • THILOPHENYL
  • TOIN
  • TOIN UNICELLES
  • ZENTRONAL
  • ZENTROPIL

Version 2.7.1