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DEXAMETHAZONE

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The Chemical Identifier fields include common identification numbers, the NFPA diamond U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 50-02-2
none
DOT Hazard Label USCG CHRIS Code
data unavailable none
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
data unavailable
General Description
PHYSICAL DESCRIPTION: Odorless white to off-white crystalline powder with a slightly bitter taste. (NTP, 1992)

The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazard
SYMPTOMS: Symptoms of exposure to this type of compound include fluid and electrolyte disturbances, pituitary-adrenal suppression, hyperglycemia, increased susceptibility to infection including tuberculosis, myopathy, growth arrest, hypokalemic alkalosis and Cushing's syndrome consisting of "moon-face", "buffalo-hump", striae, acne and hirsuitism. Other symptoms of Cushing's syndrome include enlargement of supraclavicular fat pads, "central obesity" and ecchymoses. Flushing and increased bruising may also occur with this syndrome. Other symptoms of exposure include behavioral disturbances, glycosuria, nervousness, changes in mood or psyche, psychopathies of the manic-depressive or schizophrenic type and suicidal tendencies. Exposure may cause candidiasis, gluconeogenesis, cardiac failure (in extreme cases), spontaneous fractures, increased appetite, delayed wound healing, hyperhidrosis, mental and neurological disturbances, intracranial hypertension and increase in coagulability of the blood. It may also cause peptic ulceration with perforation or hemorrhage, amenorrhea, aseptic necrosis of the bone, muscular weakness, salt and water retention, hypertension, edema, increase in severity of diabetes, pancreatitis, thrombatic episodes and osteoporosis. Other symptoms of exposure to this type of compound include sleeplessness, skin eruptions, depression, euphoria, decrease in pain sensation, weakness, deafness, convulsions, intestinal perforation in ulcerative colitis, hypokalemia, muscle degeneration, rupture of the Achilles tendon, pseudotumor cerebri and cardiac conduction defect. It may cause congestive heart failure, suppression of the immune response mechanism, impairment of glucose tolerance, habituation and unmasking of latent psychiatric disorder. It may also cause potassium loss, loss of muscle mass, vertebral compression fractures, abdominal distention, ulcerative esophagitis, thin and fragile skin, petechiae, erythema, increased sweating, suppressed reactions to skin tests, allergic dermatitis, urticaria, angioneurotic edema, vertigo, headache, menstrual irregularities, secondary adrenocorticol and pituitary unresponsiveness, decreased carbohydrate tolerance, exophthalmos, hypersensitivity, thromboembolism, malaise, weight gain, nausea and intracranial pressure with papilledema. Ascites may occur. Skin exposure to this type of compound may cause loss of skin collagen and subcutaneous atrophy. Other symptoms via this route include burning, secondary infections, itching, irritation, pigmentation, dryness, folliculitis and hypertrichosis. Eye exposure to this type of compound may lead to corneal ulceration, raised intraocular pressure, reduced visual function and cataracts. Glaucoma may also occur.

ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It may cause irritation. It may cause lacrimation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and hydrogen fluoride. (NTP, 1992)
Reactivity Profile
DEXAMETHAZONE may be sensitive to prolonged exposure to light. This chemical is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases. (NTP, 1992)
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below. More info about absorbents, including situations to watch out for...

  • Cellulose-Based Absorbents
  • Dirt/Earth

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
No information available.
Firefighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Non-Fire Response
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this material from exposure to light. Keep it away from oxidizing materials and store it under refrigerated temperatures. (NTP, 1992)
Protective Clothing
MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C22H29FO5
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: 504 to 507°F (NTP, 1992)
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
Molecular Weight: 392.47 (NTP, 1992)
Water Solubility: less than 1 mg/mL at 77°F (NTP, 1992)
Ionization Energy/Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

No PAC information available.

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

No regulatory information available.

CISA Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • AEROSEB-DEX
  • 9-ALPHA-FLUORO-11-BETA,17-ALPHA,21-TRIHYDROXY-16-ALPHA-METHYL-1,4-PREGNADIENE-
  • 9-ALPHA-FLUORO-11-BETA,17-ALPHA,21-TRIHYDROXY-16-ALPHA-METHYLPREGNA-1,4-DIENE-
  • 9-ALPHA-FLUORO-16-ALPHA-METHYL-1,4-PREGNADIENE-11-BETA,17-ALPHA,21-TRIOL-3,20-
  • 4-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-
  • 9-ALPHA-FLUORO-16-ALPHA-METHYLPREDNISOLONE
  • 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE
  • 16-ALPHA-METHYL-9-ALPHA-FLUORO-1,4-PREGNADIENE-11-BETA,17-ALPHA,21-TRIOL-3,20-
  • 16-ALPHA-METHYL-9-ALPHA-FLUORO-1-DEHYDROCORTISOL
  • 16-ALPHA-METHYL-9-ALPHA-FLUORO-11-BETA,17-ALPHA,21-TRIHYDROXYPREGNA-1,4-DIENE-
  • 16-ALPHA-METHYL-9-ALPHA-FLUORO-DELTA(SUP 1)HYDROCORTISONE
  • 16-ALPHA-METHYL-9-ALPHA-FLUOROPREDNISOLONE
  • 16ALPHA-METHYL-9ALPHA-FLUOROPREDNISOLONE
  • APHTASOLON
  • APHTHASOLONE
  • AZIUM
  • CALONAT
  • CORSONE
  • DECADERM
  • DECADRON
  • DECASONE
  • DECASPRAY
  • DECTANCYL
  • 1-DEHYDRO-16-ALPHA-METHYL-9-ALPHA-FLUOROHYDROCORTISONE
  • DEKACORT
  • DELTA(SUP 1)-9-ALPHA-FLUORO-16-ALPHA-METHYLCORTISOL
  • DELTAFLUORENE
  • DERGRAMIN
  • DERONIL
  • DESADRENE
  • DESAMETASONE
  • DESAMETHASONE
  • DESAMETON
  • DEXA
  • DEXA-CORTIDELT
  • DEXA-CORTISYL
  • DEXA-SCHEROSON
  • DEXACORT
  • DEXADELTONE
  • DEXALONA
  • DEXALTIN
  • DEXAMETH
  • DEXAMETHASONE
  • DEXAMETHASONE ALCOHOL
  • DEXAMETHAZONE
  • DEXAPOLCORT
  • DEXAPROL
  • DEXASCHEROSON
  • DEXASON
  • DEXASONE
  • DEXONE
  • DEXTELAN
  • DEZONE
  • DIONE
  • 3,20-DIONE
  • DXMS
  • 9-FLUORO-11,17,21-TRIHYDROXY-16-METHYLPREGNA-1,4-DIENE-3,20-DIONE
  • 9-FLUORO-11-BETA,17,21-TRIHYDROXY-16-ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE
  • FLUOROCORT
  • FORTECORTIN
  • GAMMACORTEN
  • HEXADECADROL
  • HEXADROL
  • HL-DEX
  • MAXIDEX
  • MEXIDEX
  • MILLICORTEN
  • MK 125
  • ORADEXON
  • PREDNISOLON F
  • PREDNISOLONE F
  • PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYL-
  • SK-DEXAMETHASONE
  • SUPERPREDNOL
  • VISUMETAZONE

Version 2.8.0