PHYSICAL DESCRIPTION: Colorless to yellow liquid. (NTP, 1992)

• Highly Flammable
• Polymerizable

Highly flammable. Water soluble. Slowly hydrolyzes in water.

This chemical is combustible. (NTP, 1992)

SYMPTOMS: Exposure to this compound in humans may cause swollen eyelids, irritation of the upper respiratory tract and painful eye irritation 6 hours past exposure. Systemic toxicity may be caused by skin contact. It causes pronounced nasal and eye irritation at 10 ppm but barely recognizable at 5 ppm after 5-minute exposure. It may also cause mucous membrane irritation. Other symptoms include severe pulmonary irritation and depression of the hematopoietic system. Other symptoms include lacrimation, clouding of the cornea, labored breathing, lung congestion, atrophy of the thymus, involution of the spleen and decreased weight gain. Causes of death are pulmonary edema and shock following extreme local irritation. It may also cause reduced or loss of spermatogenesis, leukopenia and lymphopenia.

ACUTE/CHRONIC HAZARDS: This compound is highly toxic on inhalation and moderately toxic following skin absorption or ingestion. It is readily absorbed through the skin and respiratory tract. It is irritating to the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide and carbon dioxide. (NTP, 1992)

The dl-form (CAS Registry Number 298-18-0) has been determined to be a positive animal carcinogen. (EPA, 1998)

D,L-1,2:3,4-DIEPOXYBUTANE is incompatible with acids, bases and oxidizing agents. Reacts with 4-(4'-nitrobenzyl)pyridine. Also reacts with alcohols, amines, phenols. (NTP, 1992)

• Epoxides
• Polymerizable Compounds

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below. More info about absorbents, including situations to watch out for...

• Mineral-Based & Clay-Based Absorbents
• Dirt/Earth

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 3489 datasheet.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures and away from mineral acids and bases. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• 2,2'-BIOXIRANE, (R*,R*)-(.+-.)-
• 2,2'-BIOXIRANE, (R*,R*)-
• BUTANE, 1,2:3,4-DIEPOXY-, (.+-.)-
• D,L-1,2:3,4-DIEPOXYBUTANE
• D,L-DIEPOXYBUTANE
• 1,2:3,4-DIANHYDRO-DL-THREITOL
• (+-)-1,2:3,4-DIEPOXYBUTANE
• (.+-.)-DIEPOXYBUTANE
• (.+-.)-1,2:3,4-DIEPOXYBUTANE
• 1,2,3,4-DIEPOXYBUTANE
• DL-1,2:3,4-DIEPOXYBUTANE
• (+-)-DL-1,3-BUTADIENE DIEPOXIDE
• DL-BUTADIENE DIOXIDE
• DL-DIEPOXYBUTANE
• (R*,R*)-(+-)-2,2'-BIOXIRANE
• THREITOL, 1,2:3,4-DIANHYDRO-, DL-