ISONIAZID
![](javascript:dropDownText("section1_info","section1_info_marker","/static/images/up_arrow.png","/static/images/down_arrow.png")){kind=icon}
![](javascript:dropDownText("sec1_help","sec1_help_marker","/static/images/dropdown_opened.gif","/static/images/dropdown_closed.gif"))
The
Chemical Identifier fields
include common identification numbers, the
NFPA diamond
U.S. Department of Transportation hazard labels, and a general
description of the chemical. The information in CAMEO Chemicals comes
from a variety of
data sources.
| CAS Number | UN/NA Number |
|---|---|
|
none |
| DOT Hazard Label | USCG CHRIS Code |
| data unavailable | none |
| NIOSH Pocket Guide | International Chem Safety Card |
| none |
NFPA 704
data unavailable
General Description
PHYSICAL DESCRIPTION: Odorless colorless or white crystals or white crystalline powder. Taste is slightly sweet at first and then bitter. pH (1% aqueous solution) 5.5-6.5. pH (5% aqueous solution) 6-8. (NTP, 1992)
![](javascript:dropDownText("section2_info","section2_info_marker","/static/images/up_arrow.png","/static/images/down_arrow.png")){kind=icon}
![](javascript:dropDownText("sec2_help","sec2_help_marker","/static/images/dropdown_opened.gif","/static/images/dropdown_closed.gif"))
The
Hazard fields
include
special hazard alerts
air and water
reactions, fire hazards, health hazards, a reactivity profile, and
details about
reactive groups assignments
and
potentially incompatible absorbents.
The information in CAMEO Chemicals comes from a variety of
data sources.
Reactivity Alerts
none
Air & Water Reactions
Sensitive to air and light. Absorbs insignificant amounts of moisture at 77°F at relative humidities up to approximately 90%. Water soluble. Dust can be explosive when suspended in air at specific concentrations.
Fire Hazard
This chemical is combustible. (NTP, 1992)
Health Hazard
SYMPTOMS: Symptoms of exposure to this compound include irritation of the skin, peripheral nerve sensory changes, somnolence, anorexia, sweating, respiratory depression, urine changes and toxic psychosis. Other symptoms include dizziness, paresthesias, fatal hepatitis, metabolic acidosis, convulsions and coma. It can cause headache, muscle twitching, deafness, polyneuritis, paralysis and pyridoxine deficiency. It can also cause nausea, vomiting, atropinic signs such as mydriasis, brightly colored lights and other visual hallucinations, tachycardia, peripheral neuropathy, other central nervous system reactions, stupor, exhaustion, urinary retention, liver damage, bone marrow damage and death. Exposure may cause fatigue, weakness, malaise, toxic encephalopathy, optic neuritis, optic atrophy, memory impairment, epigastric distress, elevated serum transaminases (SGOT, SGPT), bilirubinemia, bilirubinuria, jaundice, agranulocytosis hemolytic anemia, sideroblastic anemia, aplastic anemia, thrombocytopenia, eosinophilia, fever, skin eruptions (morbilliform, maculopapular, purpuric or exfoliative), lymphadenopathy, vasculitis, pellagra, hyperglycemia, gynecomastia, rheumatic syndrome, systemic lupus erythematosus-like syndrome, blurred vision, respiratory distress, central nervous system depression, severe and intractable seizures and acetonuria. Exposure may also cause gastrointestinal effects, liver necrosis, slight euphoria, irritability, nervousness, insomnia, excessive dreaming and giddiness. Other symptoms include peripheral neuritis, burning of the feet, reduction of central vision and papilledema. Hyperreflexia, vertigo, ataxia, tinnitus, hepatic reactions, hypersensitivity reactions and lethargy may occur. Constipation, difficulty in starting urination, dryness of the mouth, mood-elevating effect and mental disturbances, ranging from minor personality changes to major mental derangements. This compound may also cause skin rash, urticaria, arthritic symptoms such as back pain, bilateral proximal interphalangeal joint involvement, arthralgia of the knees, elbows and wrists and "shoulder-hand" syndrome; separation of ideas and reality, florid psychosis, loss of self-control, excessive sedation, incoordination and methemoglobinemia.
ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, mucous membranes and upper respiratory tract. It is harmful by ingestion, inhalation and skin absorption. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, ammonia and partially oxidized hydrocarbons. (NTP, 1992)
ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, mucous membranes and upper respiratory tract. It is harmful by ingestion, inhalation and skin absorption. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides, ammonia and partially oxidized hydrocarbons. (NTP, 1992)
Reactivity Profile
ISONIAZID is incompatible with chloral, aldehydes, iodine, hypochlorites and ferric salts. It is also incompatible with oxidizers. It may react with sugars and ketones. It can react as a weak acid or a weak base. It can be decomposed by oxidative and reductive reactions. (NTP, 1992)
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...
- Mineral-Based & Clay-Based Absorbents
![](javascript:dropDownText("section3_info","section3_info_marker","/static/images/up_arrow.png","/static/images/down_arrow.png")){kind=icon}
![](javascript:dropDownText("sec3_help","sec3_help_marker","/static/images/dropdown_opened.gif","/static/images/dropdown_closed.gif"))
The
Response Recommendation fields
include isolation and evacuation distances, as well as recommendations for
firefighting, non-fire response, protective clothing, and first aid. The
information in CAMEO Chemicals comes from a variety of
data sources.
Isolation and Evacuation
No information available.
Firefighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
Non-Fire Response
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under ambient temperatures. (NTP, 1992)
STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under ambient temperatures. (NTP, 1992)
Protective Clothing
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)
![](javascript:dropDownText("section4_info","section4_info_marker","/static/images/up_arrow.png","/static/images/down_arrow.png")){kind=icon}
![](javascript:dropDownText("sec4_help","sec4_help_marker","/static/images/dropdown_opened.gif","/static/images/dropdown_closed.gif"))
The
Physical Property fields
include properties such as vapor pressure and
boiling point, as well as explosive limits and
toxic exposure thresholds
The information in CAMEO Chemicals comes from a variety of
data sources.
Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circumstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.
Note: For Vapor Density and Specific Gravity, comparing the value to 1.0 can tell you if the chemical will likely sink/rise in air or sink/float in fresh water (respectively). Short phrases have been added to those values below as an aid. However, make sure to also consider the circumstances of a release. The Vapor Density comparisons are only valid when the gas escaping is at the same temperature as the surrounding air itself. If the chemical is escaping from a container where it was pressurized or refrigerated, it may first escape and behave as a heavy gas and sink in the air (even if it has a Vapor Density value less than 1). Also, the Specific Gravity comparisons are for fresh water (density 1.0 g/mL). If your spill is in salt water (density about 1.027 g/mL), you need to adjust the point of comparison. There are some chemicals that will sink in fresh water and float in salt water.
| Chemical Formula: |
|
Flash Point:
374°F
(NTP, 1992)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point:
340.5°F
(NTP, 1992)
Vapor Pressure:
Negligible
(NTP, 1992)
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
Molecular Weight:
137.14
(NTP, 1992)
Water Solubility:
greater than or equal to 100 mg/mL
at 77°F
(NTP, 1992)
Ionization Energy/Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
No AEGL information available.ERPGs (Emergency Response Planning Guidelines)
No ERPG information available.PACs (Protective Action Criteria)
No PAC information available.![](javascript:dropDownText("section5_info","section5_info_marker","/static/images/up_arrow.png","/static/images/down_arrow.png")){kind=icon}
![](javascript:dropDownText("sec5_help","sec5_help_marker","/static/images/dropdown_opened.gif","/static/images/dropdown_closed.gif"))
The
Regulatory Information fields
include information from
the U.S. Environmental Protection Agency's Title III Consolidated List of
Lists,
the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility
Anti-Terrorism Standards,
and the U.S. Occupational Safety and Health Administration's
Process Safety Management of Highly Hazardous Chemicals Standard List
(see more about these
data sources).
EPA Consolidated List of Lists
No regulatory information available.CISA Chemical Facility Anti-Terrorism Standards (CFATS)
No regulatory information available.OSHA Process Safety Management (PSM) Standard List
No regulatory information available.![](javascript:dropDownText("section6_info","section6_info_marker","/static/images/up_arrow.png","/static/images/down_arrow.png")){kind=icon}
![](javascript:dropDownText("sec6_help","sec6_help_marker","/static/images/dropdown_opened.gif","/static/images/dropdown_closed.gif"))
This section provides a listing of alternate names for this chemical,
including trade names and synonyms.
- AMIDON
- ANDRAZIDE
- ANTIMICINA
- ANTITUBERKULOSUM
- ARMACIDE
- ARMAZID
- ARMAZIDE
- ATCOTIBINE
- AZUREN
- BACILLEN
- BP 5015
- CEDIN
- CEMIDON
- CHEMIAZID
- CHEMIDON
- CORTINAZINE
- COTINAZIN
- COTINIZIN
- DEFONIN
- DIANICOTYL
- DIBUTIN
- DIFORIN
- DINACRIN
- DITUBIN
- EBIDENE
- ERALON
- ERTUBAN
- EUTIZON
- EVALON
- FIMALENE
- FSR 3
- GINK
- HIA
- HIDRANIZIL
- HIDRASONIL
- HIDRULTA
- HIDRUN
- HYCOZID
- HYDRAZID
- HYDRAZIDE
- 4-(HYDRAZINOCARBONYL)PYRIDINE
- HYOZID
- HYZYD
- I.A.I.
- IDO-TEBIN
- IDRAZIL
- IN-73
- INAH
- INH
- INIZID
- ISCOTIN
- ISIDRINA
- ISMAZIDE
- ISOBICINA
- ISOCID
- ISOCIDENE
- ISOCOTIN
- ISOLYN
- ISONERIT
- ISONEX
- ISONIACID
- ISONIAZID
- ISONIAZID SA
- ISONIAZIDE
- ISONICAZIDE
- ISONICID
- ISONICO
- ISONICOTAN
- ISONICOTIL
- ISONICOTINHYDRAZID
- ISONICOTINIC ACID HYDRAZIDE
- ISONICOTINIC HYDRAZIDE
- ISONICOTINOHYDRAZIDE
- ISONICOTINOYL HYDRAZIDE
- ISONICOTINOYLHYDRAZINE
- ISONICOTINYL HYDRAZIDE
- ISONICOTINYLHYDRAZINE
- ISONIDE
- ISONIDRIN
- ISONIKAZID
- ISONILEX
- ISONIN
- ISONINDON
- ISONIRIT
- ISONITON
- ISONIZIDE
- ISOTEBE
- ISOTEBEZID
- ISOTINYL
- ISOZIDE
- ISOZIN
- ISOZYD
- L 1945
- LANIAZID
- LANIOZID
- MYBASAN
- NEO-TIZIDE
- NEOTEBEN
- NEOXIN
- NEUMANDIN
- NEVIN
- NIADRIN
- NICAZIDE
- NICETAL
- NICIZINA
- NICONYL
- NICOTIBINA
- NICOTIBINE
- NICOTISAN
- NICOZIDE
- NIDATON
- NIDRAZID
- NIKOZID
- NIPLEN
- NITADON
- NITEBAN
- NSC 9659
- NYDRAZID
- NYSCOZID
- PELAZID
- PERCIN
- PHTHISEN
- PREPARATION 6424
- PYCAZIDE
- PYREAZID
- PYRICIDIN
- PYRIDICIN
- 4-PYRIDINECARBONYLHYDRAZINE
- 4-PYRIDINECARBOXYLIC ACID, HYDRAZIDE
- 4-PYRIDINECARBOXYLIC HYDRAZIDE
- [(4-PYRIDINYLCARBONYL)OXY]HYDRAZINE
- 4-PYRIDYLCARBONYLHYDRAZIDE
- PYRIZIDIN
- 5015 R.P.
- RAUMANON
- RAZIDE
- RETOZIDE
- RIFAMATE
- RIMICID
- RIMIFON
- RIMIPHONE
- RIMITSID
- ROBISELIN
- ROBISELLIN
- ROXIFEN
- 5015 RP
- RU-EF-TB
- SANOHIDRAZINA
- SAUTERAZID
- SAUTERZID
- STANOZIDE
- T.B. RAZIDE
- TB-PHLOGIN
- TB-RAZIDE
- TB-VIS
- TEBECID
- TEBEMID
- TEBENIC
- TEBEXIN
- TEBILON
- TEBOS
- TEEBACONIN
- TEKAZIN
- TIBAZIDE
- TIBINIDE
- TIBISON
- TIBIVIS
- TIBIZIDE
- TIBUSAN
- TISIN
- TISIODRAZIDA
- TIZIDE
- TUBAZID
- TUBAZIDE
- TUBECO
- TUBERCID
- TUBERIAN
- TUBICON
- TUBILYSIN
- TUBOMEL
- TYVID
- UNICOCYDE
- UNICOZYDE
- USAF CB-2
- VAZADRINE
- VEDERON
- ZIDAFIMIA
- ZINADON
- ZONAZIDE
Version 3.0.0