PHYSICAL DESCRIPTION: Odorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2. (NTP, 1992)

none

This compound is relatively stable at ambient temperatures. Aqueous decomposition of this chemical occurs by hydrolysis and oxidation. Insoluble in water.

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

SYMPTOMS: Symptoms of exposure to this compound include agranulocytosis, nausea, vomiting, epigastric pain, tinnitus, convulsions, coma, sodium retention, edema, aplastic anemia and leukopenia. Other symptoms include leukemia, cyanosis, respiratory depression, agitation, hallucinations, hypertension, reactivation of pre-existing peptic ulcers, ulcerative esophagitis, hepatic necrosis, glomerulonephritis, kidney stones, kidney failure, pericarditis, diffuse interstitial myocarditis with muscle necrosis, blood dyscrasias, hemolytic anemia, pancytopenia, optic neuritis causing blurred vision, toxic amblyopia, detached retina and allergic reactions such as rash, urticaria, arthralgia, Lyell's syndrome, Steven-Johnson syndrome, erythema multiforme and anaphylactic shock. It may cause kidney damage, bone marrow depression, excessive perspiring, stupor, ulceration of the buccal and gastrointestinal mucosa, cardiac toxicity, perivascular granulomata, thrombocytopenic purpura and exfoliative dermatitis. It may also cause fever, hematuria (blood in the urine), peptic ulcer, hypersensitivity reactions, hepatitis, sore throat, lesions in the mouth, dyspepsia, unusual bleeding or bruising, black or tarry stools or other evidence of intestinal ulceration, weight gain, thrombocytopenia, hemorrhagic diathesis, perforation, gastrointestinal bleeding, jaundice, death, abdominal discomfort and distress, indigestion, heartburn, water retention, abdominal distention with flatulence, constipation, diarrhea, gastritis, salivary gland enlargement, stomatitis (sometimes with ulceration), vasculitis, serum sickness, systemic lupus erythematosus, aggravation of temporal arteritis, pruritis, erythema nodosum, nonthrombocytopenic purpura, chloride retention, fluid retention, plasma dilution, congestive heart failure, metabolic acidosis, respiratory alkalosis, proteinuria, ureteral obstruction with uric acid crystals, anuria, nephrotic syndrome, impaired renal function, interstitial nephritis, headache, drowsiness, confusional states, lethargy, tremors, numbness, weakness, hyperglycemia hearing loss, scotomata, retinal hemorrhage, oculomotor palsy, thyroid hyperplasia, goiters associated with hyperthyroidism and hypothyroidism, pancreatitis, hematemesis, restlessness, dizziness, psychosis, hyperpyrexia, electrolyte disturbances, hyperventilation, hypotension, oliguria, cardiac arrest, anemia, leukocytosis and hypoprothrombinemia. Exposure may lead to vertigo, gastric irritation with ulceration, goiter, epidermal necrolysis, impaired hepati function and renal failure. Exposure may also lead to liver damage, degenerative changes in the brain, mental disturbances, difficulty in hearing, thready pulse, anorexia, pharyngeal membrane, enlargement of the liver and spleen, adrenol necrosis and uremia. Eye effects include a variety of eye disturbances, severe keratitis with involvement of the conjunctiva, cornea and tear glands which may result in scarring of the corneas with opacification vascularization and symblepharon, and rarely, diplopia. Granulocytopenia has occurred. Other symptoms may include insomnia, euphoria, nervousness and electrolyte retention.

ACUTE/CHRONIC HAZARDS: This compound is harmful if swallowed, inhaled or absorbed through the skin. It may cause irritation. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)

PHENYLBUTAZONE is incompatible with strong oxidizers, strong acids and strong bases. (NTP, 1992).

• Amides and Imides
• Azo, Diazo, Azido, Hydrazine, and Azide Compounds

No information available.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should store this chemical under ambient temperatures, and protect it from moisture. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

• ALINDOR
• ALKABUTAZONA
• ALQOVERIN
• ANERVAL
• ANPUZONE
• ANTADOL
• ANUSPIRAMIN
• ARTHRIZON
• ARTRIZIN
• ARTRIZONE
• ARTROPAN
• AZDID
• AZOBUTYL
• AZOLID
• B.T.Z.
• BENZONE
• BETAZED
• BIZOLIN 200
• BUNETZONE
• BUSONE
• BUTACOMPREN
• BUTACOTE
• BUTADION
• BUTADIONA
• BUTADIONE
• BUTAGESIC
• BUTALAN
• BUTALGINA
• BUTALIDON
• BUTALUY
• BUTAPHEN
• BUTAPIRAZOL
• BUTAPIRAZOLE
• BUTAPYRAZOLE
• BUTARECBON
• BUTARTRIL
• BUTARTRINA
• BUTAZINA
• BUTAZOLIDIN
• BUTAZOLIDINE
• BUTAZONA
• BUTAZONE
• BUTE
• BUTIDIONA
• BUTIWAS-SIMPLE
• BUTONE
• BUTOZ
• 4-BUTYL-1,2-DIPHENYL-3,5-DIOXOPYRAZOLIDINE
• 4-BUTYL-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE
• 4-BUTYL-1,2-DIPHENYLPYRAZOLIDINE-3,5-DIONE
• BUTYLPYRIN
• BUVETZONE
• BUZON
• CHEMBUTAZONE
• DA-192
• DIGIBUTINA
• DIOSSIDONE
• 3,5-DIOXE-4 BUTY-1, DIPHENYL-PYRAZOLIDINE
• 3,5-DIOXO-1,2-DIPHENYL-4-N-BUTYLPYRAZOLIDENE
• 3,5-DIOXO-1,2-DIPHENYL-4-N-BUTYLPYRAZOLIDIN
• 3,5-DIOXO-1,2-DIPHENYL-4-N-BUTYLPYRAZOLIDINE
• DIOZOL
• DIPHEBUZOL
• 1,2-DIPHENYL-2,3-DIOXO-4-N-BUTYLPYRAZOLINE
• 1,2-DIPHENYL-3,5-DIOXO-4-BUTYLPYRAZOLIDINE
• 1,2-DIPHENYL-4-BUTYL-3,5-DIOXOPYRAZOLIDINE
• 1,2-DIPHENYL-4-BUTYL-3,5-PYRAZOLIDINEDIONE
• DIPHENYLBUTAZONE
• ECOBUTAZONE
• ELMEDAL
• EQUI BUTE
• EQUIPALAZONE
• ERIBUTAZONE
• ESTEVE
• FBZ
• FEBUZINA
• FENARTIL
• FENIBUTAL
• FENIBUTASAN
• FENIBUTAZONA
• FENIBUTOL
• FENILBUTAZONA
• FENILBUTINA
• FENILBUTINE
• FENILIDINA
• FENOTONE
• FENYLBUTAZON
• FLEXAZONE
• G 13,871
• IA-BUT
• INTRABUTAZONE
• KADOL
• LINGEL
• MEPHABUTAZON
• MEPHABUTAZONE
• NADAZONE
• NCI-C56531
• PHEBUZINE
• PHENBUTAZOL
• PHENOPYRINE
• PHENYLBUTAZON
• PHENYLBUTAZONE
• PIRARREUMOL B
• PYRABUTOL
• R-3-ZON
• REUDO
• REUDOX
• REUMAZIN
• REUMUZOL
• ROBIZONE
• SCHEMERGIN
• SHIGRODIN
• TAZONE
• TENCODYNE
• TICINIL
• TODALGIL
• UZONE
• VAC-10
• WESCOZONE
• ZOLAPHEN