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METHYL CHLOROMETHYL ETHER

6.1 - Poison Inhalation Hazard 3 - Flammable liquid
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The Chemical Identifier fields include common identification numbers, the NFPA diamond, U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 107-30-2   (METHYL CHLOROMETHYL ETHER)
DOT Hazard Label USCG CHRIS Code
  • Poison Inhalation Hazard
  • Flammable Liquid
NIOSH Pocket Guide International Chem Safety Card
Chloromethyl methyl etherexternal link
NFPA 704
Diamond Hazard Value Description
3
3 2
Blue Health 3 Can cause serious or permanent injury.
Red Flammability 3 Can be ignited under almost all ambient temperature conditions.
Yellow Instability 2 Readily undergoes violent chemical changes at elevated temperatures and pressures.
White Special
(NFPA, 2010)
General Description
A clear colorless liquid. Flash point -4°F. Irritates the eyes and respiratory system. Very toxic by inhalation and may be toxic by ingestion or skin absorption. Vapors are heavier than air.

The Hazard fields include special hazard alerts, air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
  • Highly Flammable
  • Peroxidizable Compound
Air & Water Reactions
Highly flammable. Denser than water and is decomposed by water to yield hydrochloric acid, a corrosive material. With water the ether reacts to evolve formaldehyde and hydrogen chloride. The reaction is slow at ambient conditions.
Fire Hazard
Flammable/combustible material; may be ignited by heat, sparks, or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. In addition to the risk of explosion, when air mixtures of ether vapors are heated or exposed to flame or sparks, they tend to form peroxides. Ethers containing peroxides can detonate when heated. Unburned material may form powerful tear gas. When wet, also forms irritating formaldehyde gas. Evolves formaldehyde and hydrogen chloride. When heated to decomposition, it emits toxic fumes of chlorides. Avoid decomposing heat Hazardous polymerization may not occur. (EPA, 1998)
Health Hazard
The principal effect is irritation. The liquid causes severe irritation of eyes and skin; and vapor exposure of 100 ppm is severely irritating to eyes and nose. This level is dangerous to life in 4 hours. Pulmonary edema or pneumonia may cause death. There was increased death rate from respiratory cancer among exposed victims and it is a regulated carcinogen. (EPA, 1998)
Reactivity Profile
METHYL CHLOROMETHYL ETHER Is a halogenated ether. Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Ethers can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

No information available.

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions.

SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 1239 datasheet.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Firefighting
Move container from fire area. Dike fire control water for later disposal; do not scatter material. Cool containers that are exposed to flames with water. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Extinguish with dry chemicals, foam, or carbon dioxide. Water may be ineffective in extinguishing fire. (EPA, 1998)
Non-Fire Response
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:

Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors.

SMALL SPILL: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)
Protective Clothing
Skin: Wear appropriate personal protective clothing to prevent skin contact.

Eyes: Wear appropriate eye protection to prevent eye contact.

Wash skin: The worker should immediately wash the skin when it becomes contaminated. The worker should wash daily at the end of each work shift.

Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point < 100°F)

Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise.

Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)
DuPont Tychem® Suit Fabrics
Tychem® Fabric Legend
QS = Tychem 2000 SFR
QC = Tychem 2000
SL = Tychem 4000
C3 = Tychem 5000
TF = Tychem 6000
TP = Tychem 6000 FR
BR = Tychem 9000
RC = Tychem RESPONDER® CSM
TK = Tychem 10000
RF = Tychem 10000 FR
Testing Details
The fabric permeation data was generated for DuPont by independent testing laboratories using ASTM F739, EN369, EN 374-3, EN ISO 6529 (method A and B) or ASTM D6978 test methods. Normalized breakthrough times (the time at which the permeation rate is equal to 0.1 µg/cm2/min) reported in minutes. All liquid chemicals have been tested between approximately 20°C and 27°C unless otherwise stated. A different temperature may have significant influence on the breakthrough time; permeation rates typically increase with temperature. All chemicals have been tested at a concentration of greater than 95% unless otherwise stated. Unless otherwise stated, permeation was measured for single chemicals. The permeation characteristics of mixtures can deviate considerably from the permeation behavior of the individual chemicals. Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50% relative humidity per military standard MIL-STD-282.
Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP BR RC TK RF
Chloromethyl methyl ether (>95%) 107-30-2 Liquid 37 37 >480 >480 >480 >480
> indicates greater than.
A blank cell indicates the fabric has not been tested. The fabric may or may not offer barrier.

Special Warnings from DuPont

  1. Serged and bound seams are degraded by some hazardous liquid chemicals, such as strong acids, and should not be worn when these chemicals are present.
  2. CAUTION: This information is based upon technical data that DuPont believes to be reliable. It is subject to revision as additional knowledge and experience are gained. DuPont makes no guarantee of results and assumes no obligation or liability...
    ... in connection with this information. It is the user's responsibility to determine the level of toxicity and the proper personal protective equipment needed. The information set forth herein reflects laboratory performance of fabrics, not complete garments, under controlled conditions. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk. Anyone intending to use this information should first verify that the garment selected is suitable for the intended use. In many cases, seams and closures have shorter breakthrough times and higher permeation rates than the fabric. Please contact DuPont for specific data. If fabric becomes torn, abraded or punctured, or if seams or closures fail, or if attached gloves, visors, etc. are damaged, end user should discontinue use of garment to avoid potential exposure to chemical. Since conditions of use are outside our control, we make no warranties, express or implied, including, without limitation, no warranties of merchantability or fitness for a particular use and assume no liability in connection with any use of this information. This information is not intended as a license to operate under or a recommendation to infringe any patent or technical information of DuPont or others covering any material or its use.

(DuPont, 2018)

First Aid
Signs and Symptoms of Chloromethyl Methyl Ether Exposure: Acute exposure to chloromethyl methyl ether may produce severe irritation and burning of the skin, eyes, and mucous membranes. Sore throat, fever, chills, dypsnea (difficulty breathing), chronic bronchitis, and pulmonary edema with productive cough may be noted.

Emergency Life-Support Procedures: Acute exposure to chloromethyl methyl ether may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to chloromethyl methyl ether.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to chloromethyl methyl ether.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove and isolate contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. DO NOT induce vomiting or attempt to neutralize!
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C2H5ClO
Flash Point: 32 ° F (EPA, 1998)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: -154.3 ° F (EPA, 1998)
Vapor Pressure: 192 mm Hg at 70 ° F (NIOSH, 2016)
Vapor Density (Relative to Air): data unavailable
Specific Gravity: 1.0605 at 68 ° F (EPA, 1998)
Boiling Point: 138 ° F at 760 mm Hg (EPA, 1998)
Molecular Weight: 80.52 (EPA, 1998)
Water Solubility: Reacts with water (NIOSH, 2016)
Ionization Potential: 10.25 eV (NIOSH, 2016)
IDLH: A potential occupational carcinogen. (NIOSH, 2016)

AEGLs (Acute Exposure Guideline Levels)

Final AEGLs for Chloromethyl methyl ether (107-30-2)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes NR 0.6 ppm 2.6 ppm
30 minutes NR 0.6 ppm 2.6 ppm
60 minutes NR 0.47 ppm 2 ppm
4 hours NR 0.3 ppm 1.3 ppm
8 hours NR 0.22 ppm 0.93 ppm
NR = Not recommended due to insufficient data.
(NAC/NRC, 2017)

ERPGs (Emergency Response Planning Guidelines)

Chemical ERPG-1 ERPG-2 ERPG-3
Chloromethyl Methyl Ether (107-30-2) NA 1 ppm 10 ppm
NA = not appropriate.
(AIHA, 2016)

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Chloromethyl methyl ether (107-30-2) 0.043 ppm 0.47 ppm 2 ppm
(DOE, 2016)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Chloromethyl methyl ether 107-30-2 100 pounds 10 pounds 10 pounds 313 U046 5000 pounds
Methane, chloromethoxy- 107-30-2 100 pounds 10 pounds 10 pounds X U046 5000 pounds

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

RELEASE THEFT SABOTAGE
Chemical of Interest CAS Number Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
Chloromethyl methyl ether; [Methane, chloromethoxy-] 107-30-2 1.00 % 5000 pounds toxic

(DHS, 2007)

OSHA Process Safety Management (PSM) Standard List

Chemical Name CAS Number Threshold Quantity (TQ)
Chloromethyl Methyl Ether 107-30-2 500 pounds

(OSHA, 2011)

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • CHLORODIMETHYL ETHER
  • CHLOROMETHOXYMETHANE
  • CHLOROMETHYL METHYL ETHER
  • CHLOROMETHYL METHYL ETHER, [ANHYDROUS]
  • CMME
  • DIMETHYL- CHLOROETHER
  • DIMETHYLCHLOROETHER
  • ETHER DIMETHYL CHLORO
  • ETHER, CHLOROMETHYL METHYL
  • METHANE, CHLOROMETHOXY-
  • METHOXYCHLOROMETHANE
  • METHOXYMETHYL CHLORIDE
  • METHYL CHLOROMETHYL ETHER
  • METHYL CHLOROMETHYL ETHER, ANHYDROUS
  • METHYLCHLOROMETHYL ETHER
  • METHYLCHLOROMETHYL ETHER, ANHYDROUS
  • MONOCHLORODIMETHYL ETHER
  • MONOCHLOROMETHYL ETHER
  • MONOCHLOROMETHYL METHYL ETHER

Version 2.7.1