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ENDRIN

6.1 - Poison
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The Chemical Identifier fields include common identification numbers, the NFPA diamond, U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 72-20-8
DOT Hazard Label USCG CHRIS Code
  • Poison
NIOSH Pocket Guide International Chem Safety Card
Endrinexternal link
NFPA 704
data unavailable
General Description
Endrin is a white crystalline, odorless solid dissolved in a liquid carrier. It is water emulsifiable. It is toxic by inhalation, skin absorption, and/or ingestion. When heated or burned it may emit toxic hydrogen chloride and phosgene. It is used as a pesticide.

The Hazard fields include special hazard alerts, air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
No rapid reaction with air. No rapid reaction with water.
Fire Hazard
Toxic hydrogen chloride and phosgene may be generated when solution burns. Avoid strong oxidizers, strong acids and parathion. (EPA, 1998)
Health Hazard
This material is extremely toxic. It is rapidly absorbed through the skin. Symptoms appear between 20 minutes and 12 hours after exposure. There is evidence that this material may cause chromosomal damage. Doses of 1 mg/kg can cause symptoms. It is a suspected carcinogen. Also, it is a central nervous system depressant and hepatotoxin. Pregnant women are considered to be at special risk. (EPA, 1998)
Reactivity Profile
While a mixture of parathion and ENDRIN was being blended into a petroleum solvent, an exothermic reaction occurred that caused some of the petroleum solvent to vaporize. The solvent-vapor-air mixture exploded. The mechanical agitation possibly initiated the exothermic reaction, Doyle(1973). Toxic hydrogen chloride and phosgene may be generated when solution burns. Avoid strong oxidizers, strong acids and parathion. [EPA, 1998].
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below. More info about absorbents, including situations to watch out for...

  • Mineral-Based & Clay-Based Absorbents
  • Dirt/Earth

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]:

As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Firefighting
Use water to keep fire-exposed containers cool. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Wear positive pressure breathing apparatus and special protective clothing. Remove and isolate contaminated clothing at the site. Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.

Use dry chemical, foam, carbon dioxide, water spray for solution. Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. (EPA, 1998)
Non-Fire Response
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]:

Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)
Protective Clothing
Skin: Wear appropriate personal protective clothing to prevent skin contact.

Eyes: Wear appropriate eye protection to prevent eye contact.

Wash skin: The worker should immediately wash the skin when it becomes contaminated.

Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise.

Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
Note: Symptoms usually appear between 20 minutes and 12 hours after exposure.

Signs and Symptoms of Endrin Exposure: Signs and symptoms of acute exposure to endrin may be severe and include headache, dizziness, deafness, agitation, nervousness, tremors, frothing of the mouth, seizures, and coma. Convulsive episodes may alternate with periods of severe central nervous system depression. Nausea, vomiting, and diarrhea are common. Hypertension (high blood pressure), tachycardia (rapid heart rate), and cardiac arrhythmias (abnormal heart beating) may be noted. Respiratory depression may lead to respiratory arrest. Contact with the skin, eyes, and mucous membranes may result in redness and irritation. Victims often have an elevated temperature.

Emergency Life-Support Procedures: Acute exposure to endrin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to endrin.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to endrin.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas three times. Wash initially with soap and water, follow with an alcohol wash, then again with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of endrin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of endrin may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3- 1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C12H8Cl6O
Flash Point: Commercial product may contain flammable liquid with flashpoint 80F. (EPA, 1998)
Lower Explosive Limit (LEL): 1.1 % commercial product (EPA, 1998)
Upper Explosive Limit (UEL): 7 % commercial productcommercial product (EPA, 1998)
Autoignition Temperature: data unavailable
Melting Point: Decomposes at 473° F. (EPA, 1998)
Vapor Pressure: 2e-07 mm Hg at 77 ° F (EPA, 1998)
Vapor Density (Relative to Air): data unavailable
Specific Gravity: 1.7 at 68 ° F (EPA, 1998)
Boiling Point: Decomposes (NTP, 1992)
Molecular Weight: 380.9 (EPA, 1998)
Water Solubility: less than 1 mg/mL at 68° F (NTP, 1992)
Ionization Potential: data unavailable
IDLH: 2 mg/m3 (NIOSH, 2016)

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Endrin (72-20-8) 1.8 mg/m3 20 mg/m3 2000 mg/m3
(DOE, 2016)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Endrin 72-20-8 500/10000 pounds 1 pound 1 pound P051
Endrin and Metabolites N.A. &

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • (1A ALPHA, 2 BETA, 2A BETA, 3 ALPHA, 6 ALPHA, 6A BETA, 7 BETA, 7A ALPHA)-3,4,5,6,9,9,-HEXACHLORO-1A,2,2A,3,6,6A,7,7A-OCTAHYDRO-2,7:3,6-DIMETHANO-NAPH[2,3-B]OXIRENE
  • C00157
  • COMPOUND 269
  • 1,4:5,8-DIMETHANONAPHTHALENE, 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY- 1,4,4A,5,6,7,8,8A-OCTAHYDRO-,ENDO,ENDO-
  • 1,4:5,8-DIMETHANONAPHTHALENE, 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHYDRO-, ENDO,ENDO-
  • 2,7:3,6-DIMETHANONAPHTH[2,3-B]OXIRENE, 3,4,5,6,9,9-HEXACHLORO-1A,2,2A, 3,6,6A,7,7A-OCTAHYDRO-,(1AALPHA, 2BETA, 2ABETA, 3ALPHA, 6ALPHA, 6ABETA, 7BETA, 7AALPHA)-
  • 2,7:3,6-DIMETHANONAPHTH[2,3-B]OXIRENE, 3,4,5,6,9,9-HEXACHLORO-1A,2,2A,3,6,6A,7,7A-OCTAHYDRO-, (1AALPHA,2BETA,2ABETA,3ALPHA,6ALPHA,6ABETA,7BETA,7AALPHA)-
  • EN 57
  • ENDREX
  • ENDRICAL
  • ENDRICOL
  • ENDRIN
  • ENT 17,251
  • EXPERIMENTAL INSECTICIDE 269
  • 3,4,5,6,9,9-HEXACHLORO-1A,2,2A,3,6,6A,7,7A-OCTAHYDRO-2,7:3,6-DIMETHANO-NAPHTH(2,3-B)OXIRENE
  • 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY- 1,4,4A,5,6,7,8,8A-OCTAHYDRO-ENDO,ENDO-1,4:5,8-DIMETHANONAPHTHALENE
  • 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A- OCTAHYDRO-1,4:5,8-ENDO,ENDO-DIMETHANONAPHTHALENE
  • 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHYDRO- 1,4-ENDO,ENDO-5,8-DIMETHANONAPHTHALENE
  • 1,2,3,4,10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHYDRO-1,4-ENDO,ENDO-5,8-DIMETHANONAPHTHALENE
  • 1,2,3,4, 10,10-HEXACHLORO-6,7-EPOXY-1,4,4A,5,6,7,8,8A-OCTAHYDRO-ENDO-1,4-ENDO-5,8- DIMETHANONAPHTHALENE
  • HEXACHLOROEPOXYOCTAHYDRO-ENDO,ENDO- DIMETHANONAPHTHALENE
  • HEXACHLOROEPOXYOCTAHYDRO-ENDO,ENDO-DIMETHANONAPHTHALENE
  • HEXADRIN
  • HEXADRIN®
  • ISODRIN EPOXIDE
  • MENDRIN
  • NCI 01565
  • NCI-C00157
  • NENDRIN
  • OKTANEX
  • OMS 197
  • SD 3419
  • STARDRIN
  • STARDRIN 20

Version 2.7.1 rev 1