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FLUOROURACIL

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The Chemical Identifier fields include common identification numbers, the NFPA diamond U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 51-21-8
none
DOT Hazard Label USCG CHRIS Code
data unavailable none
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
data unavailable
General Description
White to nearly white crystalline powder; practically odorless. Used as an anti neoplastic drug, chemosterilant for insects. (EPA, 1998)

The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
Insoluble in water.
Fire Hazard
Emits very toxic fumes of flourides and nitrogen oxides when heated to decomposition. Avoid decomposing heat. (EPA, 1998)
Health Hazard
Minimum toxic dose in humans is approximately 450 mg/kg (total dose) over 30 days for the ingested drug. Intravenous minimum toxic dose in humans is a total dose of 6 mg/kg over three days. Depression of white blood cells occurred after intravenous administrative of a total dose of 480 mg/kg over 32 days. Occasional neuropathy and cardiac toxicity have been reported. Do not use during pregnancy. Patients with impaired hepatic or renal function, with a history of high-dose pelvic irradiation or previous use of alkylating agents should be treated with extreme caution. Patients with nutritional deficiencies and protein depletion have a reduced tolerance to fluorouracil. (EPA, 1998)
Reactivity Profile
FLUOROURACIL may be sensitive to prolonged exposure to light. Solutions discolor on storage. This chemical can react with oxidizing agents and strong bases. Incompatible with methotrexate sodium. (NTP, 1992)
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...

  • Dirt/Earth

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
No information available.
Firefighting
(Non-Specific -- Drugs or Medicines, n.o.s. (Solid) Poison B) Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear boots, protective gloves, and goggles. Wear self-contained breathing apparatus.

(Non-Specific -- Drugs or Medicines, n.o.s. (Solid) Poison B) Extinguish fire using agent suitable for type of surrounding fire (material itself burns with difficulty). Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. (EPA, 1998)
Non-Fire Response
(Non-Specific -- Drugs) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. If water pollution occurs, notify appropriate authorities. Spill or leak: shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil etc.) away from spilled material. Do not touch spilled material.

Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal.

Large spills: dike far ahead of spill for later disposal. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
Tychem® Fabric Legend
QS = Tychem 2000 SFR
QC = Tychem 2000
SL = Tychem 4000
C3 = Tychem 5000
TF = Tychem 6000
TP = Tychem 6000 FR
BR = Tychem 9000
RC = Tychem RESPONDER® CSM
TK = Tychem 10000
RF = Tychem 10000 FR
Testing Details
The fabric permeation data was generated for DuPont by independent testing laboratories using ASTM F739, EN369, EN 374-3, EN ISO 6529 (method A and B) or ASTM D6978 test methods. Normalized breakthrough times (the time at which the permeation rate is equal to 0.1 µg/cm2/min) reported in minutes. All liquid chemicals have been tested between approximately 20°C and 27°C unless otherwise stated. A different temperature may have significant influence on the breakthrough time; permeation rates typically increase with temperature. All chemicals have been tested at a concentration of greater than 95% unless otherwise stated. Unless otherwise stated, permeation was measured for single chemicals. The permeation characteristics of mixtures can deviate considerably from the permeation behavior of the individual chemicals. Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50% relative humidity per military standard MIL-STD-282.
Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP BR RC TK RF
Fluorouracil, 5- (50 mg/ml, 1 N NH3OH) 51-21-8 Liquid >240
> indicates greater than.
A blank cell indicates the fabric has not been tested. The fabric may or may not offer barrier.

Special Warnings from DuPont

  1. Serged and bound seams are degraded by some hazardous liquid chemicals, such as strong acids, and should not be worn when these chemicals are present.
  2. CAUTION: This information is based upon technical data that DuPont believes to be reliable. It is subject to revision as additional knowledge and experience are gained. DuPont makes no guarantee of results and assumes no obligation or liability...
    ... in connection with this information. It is the user's responsibility to determine the level of toxicity and the proper personal protective equipment needed. The information set forth herein reflects laboratory performance of fabrics, not complete garments, under controlled conditions. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk. Anyone intending to use this information should first verify that the garment selected is suitable for the intended use. In many cases, seams and closures have shorter breakthrough times and higher permeation rates than the fabric. Please contact DuPont for specific data. If fabric becomes torn, abraded or punctured, or if seams or closures fail, or if attached gloves, visors, etc. are damaged, end user should discontinue use of garment to avoid potential exposure to chemical. Since conditions of use are outside our control, we make no warranties, express or implied, including, without limitation, no warranties of merchantability or fitness for a particular use and assume no liability in connection with any use of this information. This information is not intended as a license to operate under or a recommendation to infringe any patent or technical information of DuPont or others covering any material or its use.

(DuPont, 2018)

First Aid
Signs and Symptoms of Acute Fluorouracil Exposure: Nausea, vomiting, and diarrhea are the earliest symptoms of exposure to fluorouracil. Inflammation or sores in the mouth, gastric burning, and gastrointestinal bleeding may occur in more severe cases. Other symptoms include visual disturbances, lacrimation (tearing), chest pain and tachycardia (rapid heart rate).

Emergency Life-Support Procedures: Acute exposure to fluorouracil may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to fluorouracil.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to fluorouracil.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of fluorouracil is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3- 1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C4H3FN2O2
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: Decomposes at 540-541° F (EPA, 1998)
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
Molecular Weight: 130.08 (EPA, 1998)
Water Solubility: less than 1 mg/mL at 66° F (NTP, 1992)
Ionization Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Fluorouracil (51-21-8) 1.7 mg/m3 19 mg/m3 46 mg/m3
(DOE, 2016)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
5-Fluorouracil 51-21-8 500/10000 pounds 500 pounds X
Fluorouracil 51-21-8 500/10000 pounds 500 pounds 313

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • ADRUCIL
  • ARUMEL
  • CARZONAL
  • 2,4-DIOXO-5-FLUOROPYRIMIDINE
  • EFFLUDERM (FREE BASE)
  • EFUDEX
  • EFUDIX
  • EFURIX
  • FLUORO URACIL
  • 5-FLUORO- 2,4-PYRIMIDINEDIONE
  • 5-FLUORO-2,4(1H,3H)-PYRIMIDINEDIONE
  • 5-FLUORO-2,4-PYRIMIDINEDIONE
  • FLUOROBLASTIN
  • FLUOROPLEX
  • 5-FLUOROPYRIMIDINE- 2,4-DIONE
  • 5-FLUOROPYRIMIDINE-2,4-DIONE
  • FLUOROURACIL
  • 5-FLUOROURACIL
  • FLURACIL
  • FLURACILUM
  • FLURI
  • FLURIL
  • FT-207
  • FTORURACIL
  • FU
  • 5-FU
  • 2,4(1H,3H)-PYRIMIDINEDIONE, 5-FLUORO-
  • NSC 19893
  • NSC-19893
  • QUEROPLEX
  • RO 2-9757
  • TIMAZIN
  • U-8953
  • ULUP
  • URACIL, 5-FLUORO-

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