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WARFARIN

6.1 - Poison
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The Chemical Identifier fields include common identification numbers, the NFPA diamond, U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 81-81-2
DOT Hazard Label USCG CHRIS Code
  • Poison
none
NIOSH Pocket Guide International Chem Safety Card
Warfarinexternal link
NFPA 704
data unavailable
General Description
Odorless and colorless solid. Used as a rodenticide for Norway rats and for house mice. (EPA, 1998)

The Hazard fields include special hazard alerts, air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
No rapid reaction with air. No rapid reaction with water.
Fire Hazard
Contact with strong oxidizers may cause fires and explosions. Toxic gases and vapors (e.g., carbon monoxide) may be released in heating to decomposition. Avoid strong oxidizers. (EPA, 1998)
Health Hazard
It is classified as very toxic. Probable oral lethal dose in humans is 50-500 mg/kg, between 1 teaspoon and 1 ounce for a 150 lb. person. Material is an anticoagulant. Toxic effects other than hemorrhage are rarely seen in humans. Material is believed to be teratogenic in humans. Persons with a history of blood disorders with bleeding tendencies would be expected to be at increased risk from exposure. (EPA, 1998)
Reactivity Profile
WARFARIN is incompatible with the following: Strong oxidizers (NIOSH, 2016).
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...

  • Cellulose-Based Absorbents

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]:

As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Firefighting
(Non-Specific -- Poison B Solid) Wear full protective clothing and self-contained breathing apparatus.

(Non-Specific -- Poison B Solid) Extinguish fire using agent suitable for type of surrounding fire. Use alcohol foam, carbon dioxide, or dry chemical. (EPA, 1998)
Non-Fire Response
Do not touch spilled material. Eating and smoking should not be permitted in areas where it is handled, processed or stored. For small spills: sweep onto paper or other suitable material. Place in an appropriate container and burn in a safe place. Large quantities may be destroyed by dissolving in a flammable solvent (e.g., alcohol) and atomizing in a combustion chamber. (EPA, 1998)
Protective Clothing
Skin: Wear appropriate personal protective clothing to prevent skin contact.

Eyes: No recommendation is made specifying the need for eye protection.

Wash skin: The worker should immediately wash the skin when it becomes contaminated.

Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise. (NIOSH, 2016)
DuPont Tychem® Suit Fabrics
No information available.
First Aid
Signs and Symptoms of Warfarin Exposure: Warfarin is an anticoagulant. Hemorrhage is the most common sign and may be manifested by hemorrhagic skin rashes and lip, nose, and upper airway bleeding. Upper airway pain, difficulty in speaking and swallowing, and dyspnea (shortness of breath) may occur. Vomiting, abdominal pain, and bloody stools are common. Back pain may be noted.

Emergency Life-Support Procedures: Acute exposure to warfarin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to warfarin.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to warfarin.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas thoroughly with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of warfarin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.Warning: Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C19H16O4
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: 322 ° F (EPA, 1998)
Vapor Pressure: 0.09 mm Hg at 71 ° F (NIOSH, 2016)
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: Decomposes (NIOSH, 2016)
Molecular Weight: 308.32 (EPA, 1998)
Water Solubility: 0.002 % (NIOSH, 2016)
Ionization Potential: data unavailable
IDLH: 100 mg/m3 (as warfarin) (NIOSH, 2016)

AEGLs (Acute Exposure Guideline Levels)

No AEGL information available.

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Warfarin (81-81-2) 1.8 mg/m3 20 mg/m3 350 mg/m3
(DOE, 2016)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Warfarin 81-81-2 500/10000 pounds 100 pounds 100 pounds X 313c P001
Warfarin, & salts, conc.>0.3% 81-81-2 100 pounds X 313c P001

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • 3-(ACETONYLBENZYL)- 4-HYDROXYCOUMARIN
  • 3-(ALPHA-ACETONYL)-BENZYL-4-HYDROXYCOUMARIN
  • 3-(ALPHA-ACETONYLBENZYL)-4-HYDROXYCOUMARIN
  • 3-(ALPHA-PHENYL-BETA- ACETYLETHYL)-4-HYDROXYCOUMARIN
  • 3-(ALPHA-PHENYL-BETA-ACETYLETHYL)-4-HYDROXYCOUMARIN
  • ARAB RAT DEATH
  • ATHROMBIN-K
  • ATHROMBINE-K
  • BRUMOLIN
  • CO-RAX
  • COMPOUND 42
  • COUMADIN
  • COUMAFEN
  • COUMAFENE
  • COUMAPHEN
  • COUMARIN, 3-(ALPHA- ACETONYLBENZYL)-4-HYDROXY
  • COUMARIN, 3-(ALPHA-ACETONYLBENZYL)-4-HYDROXY-
  • COUMARIN, 4-HYDROXY-3(1-PHENYL-3-OXO-BUTYL)-
  • COUMARIN,3-(ALPHA-ACETONYLBENZYL)-4-HYDROXY-
  • 200 COUMARIN
  • COUMEFENE
  • COV-R-TOX
  • D-CON
  • DETHMOR
  • DETHNEL
  • DL-3-(ALPHA-ACETONYLBENZYL)-4-HYDROXYCOUMARIN
  • EASTERN STATES DUOCIDE
  • FASCO FASCRAT POWDER
  • FRASS-RATRON
  • 2H-1-BENZOPYRAN-2-ONE, 4-HYDROXY-3-(3-OXO-1-PHENYLBUTYL)
  • 2HK-1-BENZOPYTAN-2-ONE,4-HYDROXY-3-(3-OXO-1-PHENYL BUTYL)-(9CI)
  • 1-(4'-HYDROXY- 3'-COUMARINYL)-1-PHENYL-3-BUTANONE
  • 4-HYDROXY-3(3-OXO-1-PHENYLBUTYL)-2H-1-BENZOPYRAN-2-ONE
  • 4-HYDROXY-3-(3-OXO-1-PHENYL BUTYL)-2H-1-BENZOPYRAN-2-ONE
  • KUMADER
  • KUMADU
  • KUMATOX
  • KYPFARIN
  • LIQUA-TOX
  • MAAG RATTENTOD CUM
  • MAR-FRIN
  • MARTIN'S MAR-FRIN
  • MARTIN`S MAR-FRIN
  • MAVERAN
  • MOUSE- PAK
  • 3-(1'-PHENYL-2'- ACETYLETHYL)-4-HYDROXYCOUMARIN
  • 3-(1'-PHENYL-2'-ACETYLETHYL)-4-HYDROXYCOUMARIN
  • PROTHROMADIN
  • RAC-WARFARIN
  • RAT AND MICE BAIT
  • RAT-A-WAY
  • RAT-B-GON
  • RAT-GARD
  • RAT-KILL
  • RAT-MIX
  • RAT-O-CIDE #2
  • RAT-OLA
  • RAT-TROL
  • RATOREX
  • RATOX
  • RATOXIN
  • RATRON
  • RATRON G
  • RATS-NO-MORE
  • RATTUNAL
  • RAX
  • RO-DETH
  • RODAFARIN
  • RODAFARIN C
  • RODEX, RODEX BLOX
  • ROSEX
  • ROUGH AND READY MOUSE MIX
  • (RS)-WARFARIN
  • SOLFARIN
  • SPRAY-TROL BRAND RODEN-TROL
  • TEMUS W
  • TOX-HID
  • TWIN LIGHT RAT AWAY
  • VAMPIRINIP II
  • VAMPIRINIP II& III
  • VAMPIRINIP III
  • W.A.R.F. 42
  • WARAN
  • WARF
  • WARF 42
  • WARF COMPOUND 42
  • WARF-12
  • WARFARAT
  • WARFARIN
  • WARFARIN PLUS
  • WARFARIN Q
  • (.+-.)-WARFARIN
  • WARFARIN, & SALTS, CONC.>0.3%
  • (.+-.)-WARFARIN-ALCOHOL
  • WARFICIDE
  • ZOOCOUMARIN

Version 2.7.1