Get the app in the App Store and on Google Play!

PARATHION

6.1 - Poison
Add to MyChemicals

The Chemical Identifier fields include common identification numbers, the NFPA diamond, U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 56-38-2
DOT Hazard Label USCG CHRIS Code
  • Poison
NIOSH Pocket Guide International Chem Safety Card
Parathionexternal link
NFPA 704
data unavailable
General Description
Parathion is a deep brown to yellow liquid with a faint odor of garlic. It is an organic phosphate insecticide which acts as an inhibitor of cholinesterase, and as such it is highly toxic by all routes of exposure. It may be found as a liquid or as a dry mixture where the liquid is absorbed onto a dry carrier.

The Hazard fields include special hazard alerts, air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
Slightly soluble in water.
Fire Hazard
When heated to decomposition, it can emit toxic fumes of oxides of nitrogen, phosphorus, and sulfur. High pressure hoses may scatter material from broken containers. Containers may explode when heated. Stable in distilled water and in acid solution. Store below 77-86F. It slowly decomposes in air and hydrolyzes in the presence of alkaline material. Containers may explode when heated. (EPA, 1998)
Health Hazard
This material is extremely toxic; the probable oral lethal dose is 5-50 mg/kg, or between 7 drops and 1 teaspoonful for a 150-lb. person. As little as 1 drop can endanger life if splashed in the eye. Toxicity is highest by inhalation. People at special risk are those with a history of glaucoma, cardiovascular disease, hepatic disease, renal disease, or central nervous system abnormalities. (EPA, 1998)
Reactivity Profile
Light-yellow liquid, it turns solid at 6° C, a deadly poison by all routes. Organic phosphate insecticide, acts as an inhibitor of cholinesterase. Violent reaction when used as solvent to dissolve endrin. When heated to decomposition it emits very toxic fumes of oxides of sulfur, phosphorus, and nitrogen [Lewis, 3rd ed., 1993, p. 984].
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbents listed below. More info about absorbents, including situations to watch out for...

  • Cellulose-Based Absorbents
  • Expanded Polymeric Absorbents

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:

As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Firefighting
Use water spray to keep fire-exposed containers cool. If a leak or spill has not ignited, use water spray to disperse vapors and to provide protection for firefighters. Water spray may be used to flush spills away from exposures. Fight advanced or massive fires from a safe distance or from a protected location. Special protective clothing should be worn; normal protective clothing may be penetrated.

Use water spray, dry chemical, foam, or carbon dioxide. (EPA, 1998)
Non-Fire Response
In case of leaks or spills, special protective clothing should be worn. Use water spray to disperse vapors and flush spills away.
Ventilate area of spill or leak. Spills may be absorbed in vermiculite, dry sand, earth, or a similar material. (EPA, 1998)
Protective Clothing
Skin: Wear appropriate personal protective clothing to prevent skin contact.

Eyes: Wear appropriate eye protection to prevent eye contact.

Wash skin: The worker should immediately wash the skin when it becomes contaminated.

Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced.

Change: Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premise.

Provide: Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)
DuPont Tychem® Suit Fabrics
Tychem® Fabric Legend
QS = Tychem 2000 SFR
QC = Tychem 2000
SL = Tychem 4000
C3 = Tychem 5000
TF = Tychem 6000
TP = Tychem 6000 FR
BR = Tychem 9000
RC = Tychem RESPONDER® CSM
TK = Tychem 10000
RF = Tychem 10000 FR
Testing Details
The fabric permeation data was generated for DuPont by independent testing laboratories using ASTM F739, EN369, EN 374-3, EN ISO 6529 (method A and B) or ASTM D6978 test methods. Normalized breakthrough times (the time at which the permeation rate is equal to 0.1 µg/cm2/min) reported in minutes. All liquid chemicals have been tested between approximately 20°C and 27°C unless otherwise stated. A different temperature may have significant influence on the breakthrough time; permeation rates typically increase with temperature. All chemicals have been tested at a concentration of greater than 95% unless otherwise stated. Unless otherwise stated, permeation was measured for single chemicals. The permeation characteristics of mixtures can deviate considerably from the permeation behavior of the individual chemicals. Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50% relative humidity per military standard MIL-STD-282.
Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP BR RC TK RF
Ethyl parathion (>95%) 56-38-2 Liquid >480 >480 >480 >480
> indicates greater than.
A blank cell indicates the fabric has not been tested. The fabric may or may not offer barrier.

Special Warnings from DuPont

  1. Serged and bound seams are degraded by some hazardous liquid chemicals, such as strong acids, and should not be worn when these chemicals are present.
  2. CAUTION: This information is based upon technical data that DuPont believes to be reliable. It is subject to revision as additional knowledge and experience are gained. DuPont makes no guarantee of results and assumes no obligation or liability...
    ... in connection with this information. It is the user's responsibility to determine the level of toxicity and the proper personal protective equipment needed. The information set forth herein reflects laboratory performance of fabrics, not complete garments, under controlled conditions. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk. Anyone intending to use this information should first verify that the garment selected is suitable for the intended use. In many cases, seams and closures have shorter breakthrough times and higher permeation rates than the fabric. Please contact DuPont for specific data. If fabric becomes torn, abraded or punctured, or if seams or closures fail, or if attached gloves, visors, etc. are damaged, end user should discontinue use of garment to avoid potential exposure to chemical. Since conditions of use are outside our control, we make no warranties, express or implied, including, without limitation, no warranties of merchantability or fitness for a particular use and assume no liability in connection with any use of this information. This information is not intended as a license to operate under or a recommendation to infringe any patent or technical information of DuPont or others covering any material or its use.

(DuPont, 2018)

First Aid
CAUTION: Parathion is a cholinestorase inhibitor. It has been reported that as little as one drop of parathion can endanger life if splashed in the eye. Toxicity is highest by inhalation.

Signs and Symptoms of Acute Parathion Exposure: Acute exposure to parathion may produce the following signs and symptoms: pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur.

Emergency Life-Support Procedures: Acute exposure to parathion may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to parathion.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to parathion.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of parathion is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4.Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of parathion may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C10H14NO5PS
Flash Point: 248 to 320 ° F (EPA, 1998)
Lower Explosive Limit (LEL): Not highly flammable. (EPA, 1998)
Upper Explosive Limit (UEL): Not highly flammable. (EPA, 1998)
Autoignition Temperature: data unavailable
Melting Point: 43 ° F (EPA, 1998)
Vapor Pressure: 3.78e-05 mm Hg at 68 ° F (EPA, 1998)
Vapor Density (Relative to Air): data unavailable
Specific Gravity: 1.26 (EPA, 1998)
Boiling Point: 707 ° F at 760 mm Hg (EPA, 1998)
Molecular Weight: 291.27 (EPA, 1998)
Water Solubility: less than 1 mg/mL at 73° F (NTP, 1992)
Ionization Potential: data unavailable
IDLH: 10 mg/m3 (as parathion) (NIOSH, 2016)

AEGLs (Acute Exposure Guideline Levels)

Interim AEGLs for Parathion (56-38-2)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes NR 2.8 mg/m3 3.6 mg/m3
30 minutes NR 1.9 mg/m3 2.5 mg/m3
60 minutes NR 1.5 mg/m3 2 mg/m3
4 hours NR 0.96 mg/m3 1.3 mg/m3
8 hours NR 0.48 mg/m3 0.63 mg/m3
NR = Not recommended due to insufficient data
(NAC/NRC, 2017)

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Parathion (56-38-2) 0.15 mg/m3 1.5 mg/m3 2 mg/m3
(DOE, 2016)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Parathion 56-38-2 100 pounds 10 pounds 10 pounds 313 P089
Phosphorothioic acid, O,O-diethyl-O-(4-nitrophenyl) ester 56-38-2 100 pounds 10 pounds 10 pounds X P089

(EPA List of Lists, 2015)

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • AAT
  • AATP
  • AC 3422
  • ACC 3422
  • ALKRON
  • ALLERON
  • AMERICAN CYANAMID 3422
  • APHAMITE
  • ARALO
  • B 404
  • BAY 1605
  • BAY E-605
  • BAYER E-605
  • BLADAN
  • BLADAN F
  • COMPOUND 3422
  • COROTHION
  • CORTHION
  • CORTHIONE
  • DANTHION
  • DIETHYL 4-NITROPHENYL PHOSPHOROTHIOATE
  • DIETHYL 4-NITROPHENYL PHOSPHOROTHIONATE
  • DIETHYL P-NITROPHENYL PHOSPHOROTHIONATE
  • DIETHYL P-NITROPHENYL THIONOPHOSPHATE
  • DIETHYL P-NITROPHENYL THIOPHOSPHATE
  • DIETHYL PARA-NITROPHENOL THIOPHOSPHATE
  • DIETHYL PARATHION
  • DIETHYL-P-NITROPHENYL MONOTHIOPHOSPHATE
  • DIETHYLPARATHION
  • DNTP
  • DPP
  • DREXEL PARATHION 8E
  • E 605
  • E 605 F
  • E 605 FORTE
  • E 605F
  • E 605FT20
  • ECATOX
  • ECATOX 20
  • EKATIN WF & WF ULV
  • EKATOX
  • EKATOX 20
  • ENT 15,108
  • ETHLON
  • ETHYL PARATHION
  • ETILON
  • FOLIDOL
  • FOLIDOL E
  • FOLIDOL E & E 605
  • FOLIDOL E-605
  • FOLIDOL E605
  • FOLIDOL OIL
  • FOSFERMO
  • FOSFERNO
  • FOSFEX
  • FOSFIVE
  • FOSOVA
  • FOSTERN
  • FOSTOX
  • GEARPHOS
  • GENITHION
  • KOLPHOS
  • KYPTHION
  • LETHALAIRE G-54
  • LIROTHION
  • MURFOS
  • NCI-C00226
  • NIRAN
  • NIRAN E-4
  • NITROSTIGMINE
  • NITROSTYGMINE
  • NIUIF 100
  • NIUIF-100
  • NOURITHION
  • O,O-DIETHYL O-(4-NITROPHENYL) PHOSPHOROTHIOATE
  • O,O-DIETHYL O-(P-NITROPHENYL) PHOSPHOROTHIOATE
  • O,O-DIETHYL O-(P-NITROPHENYL) THIONOPHOSPHATE
  • O,O-DIETHYL O-4-NITROPHENYL THIOPHOSPHATE
  • O,O-DIETHYL O-P- NITROPHENYL PHOSPHOROTHIOATE
  • O,O-DIETHYL O-P-NITROPHENYL THIOPHOSPHATE
  • O,O-DIETHYL-O(P-NITROPHENYL) PHOSPHOROTHIOATE
  • O,O-DIETHYL-O-(P-NITROPHENYL)THIONOPHOSPHATE
  • OLEOFOS 20
  • OLEOPARAPHENE
  • OLEOPARATHENE
  • OLEOPARATHION
  • OMS 19
  • ORTHOPHOS
  • P-NITROPHENOL O-ESTER WITH O,O-DIETHYLPHOSPHOROTHIOATE
  • PAC
  • PACOL
  • PANTHION
  • PARADUST
  • PARAFLOW
  • PARAMAR
  • PARAMAR 50
  • PARAPHOS
  • PARATHENE
  • PARATHION
  • PARATHION-ETHYL
  • PARAWET
  • PENNCAP E
  • PESTOX PLUS
  • PETHION
  • PHENPHOS
  • PHOSKIL
  • PHOSPHEMOL
  • PHOSPHENOL
  • PHOSPHOROTHIOIC ACID O,O-DIETHYL O-(4-NITROPHENYL) ESTER
  • PHOSPHOROTHIOIC ACID, O,O-DIETHYL O-(P-NITROPHENYL) ESTER
  • PHOSPHOROTHIOIC ACID, O,O-DIETHYL-O-(4-NITROPHENYL) ESTER
  • PHOSPHOROTHIOIC ACID, O,O-DIETHYL-O-(P-NITROPHENYL) ESTER
  • PHOSPHOROTHIOIC ACID, O,O-DIETHYL-O-P-NITROPHENYL ESTER
  • PHOSPHOSTIGMINE
  • RB
  • RHODIASOL
  • RHODIATOX
  • RHODIATROX
  • SELEPHOS
  • SIXTY-THREE SPECIAL E.C. INSECTICIDE
  • SNP
  • SOPRATHION
  • STABILIZED ETHYL PARATHION
  • STATHION
  • STRATHION
  • SULPHOS
  • SUPER RODIATOX
  • T-47
  • THIOFOS
  • THIOMEX
  • THIOPHOS
  • THIOPHOS 3422
  • TIOFOS
  • TOX 47
  • VAPOPHOS
  • VITREX

Version 2.7.1 rev 1