Chemical Identifier fields
include common identification numbers, the
U.S. Department of Transportation hazard labels, and a general
description of the chemical. The information in CAMEO Chemicals comes
from a variety of
|DOT Hazard Label
||USCG CHRIS Code
|NIOSH Pocket Guide
||International Chem Safety Card
PHYSICAL DESCRIPTION: An anticancer drug. White to slightly yellow, amorphous or crystalline powder. Sensitive to light. Odorless. pH (0.1% solution) 3.5 - 4.5. (NTP, 1992)
Air & Water Reactions
Very hygroscopic. Water soluble.
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
SYMPTOMS: The following symptoms of exposure have occurred during intravenous use. Symptoms of exposure include bone marrow depression, peripheral neuropathy, colicky abdominal pain, constipation and alopecia. Other symptoms include neuromuscular and neurological disturbances, gastrointestinal upset and leucopenia. It has caused impaired walking, convulsions, hypertension, inappropriate antidiuretic hormone (ADH) secretion, jaw pain, paresthesias in the fingers and toes, sensory impairment, headache, loss of deep tendon reflexes, parotid gland pain, optic atrophy and blindness. It has also caused acute uric acid nephropathy, myocardial infarction, ocular toxicity (ptosis, other ocular muscle paresis, and 5th and 7th nerve involvement); laryngeal nerve paralysis causing hoarseness or cough, depression of the Achilles tendon reflex, muscle pain, weakness, motor weakness, quadriparesis, numbness and tingling of the fingers and toes, malaise, depression, psychoses, neuromyopathy, peripheral neuritis, adynamic ileus, and permanent central nervous system damage. Exposure may cause paresthesia, foot drop, ataxia, athetosis, thrombocytosis and coma. Exposure may also cause granulocytopenia, thrombocytopenia, hypoplasia of all elements of bone marrow, nausea, vomiting, anorexia, neuritic pain and motor difficulties. Other effects may include cranial nerve neuropathy including optic nerve neuropathy and injury to the retina; cataracts, facial paralysis, diplopia and corneal hypesthesia. It may cause anemia, polyuria, dysuria, fever, tingling and numbness of the extremities, abdominal obstruction, ischemic cardiac toxicity and syndrome of hyponatremia. It may also cause diarrhea, sensory loss, slapping gait, muscle wasting, generalized sensorimotor dysfunction, paralytic ileus, abdominal cramps, rash, oral ulceration, intestinal necrosis and/or perforation, urinary retention due to bladder atony cranial nerve manifestations including isolated paresis and/or paralysis of muscles controlled by cranial motor nerves; pharyngeal pain, bone pain, back pain, limb pain, myalgias, renal or adrenal disease, hypotension, dehydration, azotemia and clinical edema. Effects on the autonomic nervous system have been reported. It may cause irritation of the skin, and congenital malformation in the fetus.
ACUTE/CHRONIC HAZARDS: This compound is highly toxic and may be fatal if inhaled, swallowed or absorbed through the skin. It may cause irritation of the skin. When heated to decomposition it emits very toxic fumes of carbon monoxide, carbon dioxide, nitrogen oxides and sulfur oxides. (NTP, 1992)
Sensitive to hydrolysis, oxidation and heat. Incompatible with strong oxidizing agents. (NTP, 1992).
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents
Use caution: Liquids with this reactive group classification have been
known to react with the
More info about absorbents, including situations to watch out for...
- Cellulose-Based Absorbents
Response Recommendation fields
include isolation and evacuation distances, as well as recommendations for
firefighting, non-fire response, protective clothing, and first aid. The
information in CAMEO Chemicals comes from a variety of
Isolation and Evacuation
Excerpt from ERG Guide 151
[Substances - Toxic (Non-combustible)]:
As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.
FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
DuPont Tychem® Suit Fabrics
Tychem® Fabric Legend
|QS = Tychem 2000 SFR
|QC = Tychem 2000
|SL = Tychem 4000
|C3 = Tychem 5000
|TF = Tychem 6000
|TP = Tychem 6000 FR
|BR = Tychem 9000
|RC = Tychem RESPONDER® CSM
|TK = Tychem 10000
|RF = Tychem 10000 FR
The fabric permeation data was generated for DuPont by independent
testing laboratories using ASTM F739, EN369, EN 374-3, EN ISO 6529
(method A and B) or ASTM D6978 test methods.
Normalized breakthrough times
(the time at which the permeation rate is equal to 0.1 µg/cm2/min)
reported in minutes.
All liquid chemicals have been tested between approximately 20°C and
27°C unless otherwise stated.
A different temperature may have significant influence on the
breakthrough time; permeation rates typically increase with
All chemicals have
been tested at a concentration of greater than 95% unless otherwise
Unless otherwise stated, permeation was measured for single chemicals.
The permeation characteristics of mixtures can deviate considerably
from the permeation behavior of the individual chemicals.
Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur
Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50%
relative humidity per military standard MIL-STD-282.
Normalized Breakthrough Times (in Minutes)
|Vincristine sulfate (1 mg/ml)
Special Warnings from DuPont
- Serged and bound seams are degraded by some hazardous liquid
chemicals, such as strong acids, and should not be worn when
these chemicals are present.
CAUTION: This information is based upon technical data that
DuPont believes to be reliable. It is subject to revision as
additional knowledge and experience are gained. DuPont makes no
guarantee of results and assumes no obligation or liability...
... in connection with this information. It is the user's responsibility to
determine the level of toxicity and the proper personal protective
equipment needed. The information set forth herein reflects laboratory
performance of fabrics, not complete garments, under controlled conditions.
It is intended for informational use by persons having technical skill for
evaluation under their specific end-use conditions, at their own discretion
and risk. Anyone intending to use this information should first verify
that the garment selected is suitable for the intended use. In many cases,
seams and closures have shorter breakthrough times and higher permeation
rates than the fabric. Please contact DuPont for specific data. If fabric
becomes torn, abraded or punctured, or if seams or closures fail, or if
attached gloves, visors, etc. are damaged, end user should discontinue use
of garment to avoid potential exposure to chemical. Since conditions of use
are outside our control, we make no warranties, express or implied,
including, without limitation, no warranties of merchantability or fitness
for a particular use and assume no liability in connection with any use of
this information. This information is not intended as a license to operate
under or a recommendation to infringe any patent or technical information
of DuPont or others covering any material or its use.
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. Strychnine is an exceptionally toxic poison but inducing vomiting may cause a seizure. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Flash Point: data unavailable
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
531 ° F
Vapor Pressure: data unavailable
Vapor Density (Relative to Air): data unavailable
Specific Gravity: data unavailable
Boiling Point: data unavailable
greater than or equal to 10 mg/mL
at 75° F
Ionization Potential: data unavailable
IDLH: data unavailable
AEGLs (Acute Exposure Guideline Levels)
No AEGL information available.
ERPGs (Emergency Response Planning Guidelines)
No ERPG information available.
PACs (Protective Action Criteria)
No PAC information available.
Regulatory Information fields
include information from
the U.S. Environmental Protection Agency's Title III Consolidated List of
the U.S. Department of Homeland Security's Chemical Facility
and the U.S. Occupational Safety and Health Administration's
Process Safety Management of Highly Hazardous Chemicals Standard List
(see more about these
EPA Consolidated List of Lists
No regulatory information available.
DHS Chemical Facility Anti-Terrorism Standards (CFATS)
No regulatory information available.
OSHA Process Safety Management (PSM) Standard List
No regulatory information available.
This section provides a listing of alternate names for this chemical,
including trade names and synonyms.
- DES-NA-METHYL-NA-FORMYLVINBLASTINE SULPHATE
- 2H-3,7-METHANOAZACYCLOUNDECINO[5,4-B]INDOLE, VINCALEUKOBLASTINE DERIV.
- 1H-INDOLIZINO[8,1-CD]CARBAZOLE, VINCALEUKOBLASTINE DERIV.
- LCR SULPHATE
- LEUROCRISTINE SULFATE
- LEUROCRISTINE SULFATE (1:1)
- LEUROCRISTINE SULFATE (1:1) (SALT)
- LEUROCRISTINE SULPHATE
- LEUROCRISTINE, SULFATE (1:1) (SALT)
- LILLY 37231
- NSC 67574
- 22-OXOVINCALEUKOBLASTINE SULFATE (1:1) (SALT)
- 22-OXOVINCALEUKOBLASTINE SULFATE
- VCR SULFATE
- VCR SULPHATE
- VINCRISTINE SULFATE
Version 2.7.1 rev 1