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PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL) O-ETHYL ESTER

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The Chemical Identifier fields include common identification numbers, the NFPA diamond U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 50782-69-9
none
DOT Hazard Label USCG CHRIS Code
data unavailable none
NIOSH Pocket Guide International Chem Safety Card
none none
NFPA 704
data unavailable
General Description
Odorless liquid, with an amber color. Used as a quick-acting military chemical nerve agent.

The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
none
Air & Water Reactions
No rapid reaction with air. No rapid reaction with water.
Fire Hazard
Highly toxic nitrogen oxides and sulfur oxides. Avoid extreme heat. (EPA, 1998)
Health Hazard
Cholinesterase inhibitor. Lowest toxic oral dose (TDLO) to humans is 4 mg/kg; lowest lethal skin dose to humans (LDLO) is 86 mg/kg. Death within 15 minutes after fatal dose is absorbed. (EPA, 1998)
Reactivity Profile
Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

Use caution: Liquids with this reactive group classification have been known to react with the absorbent listed below. More info about absorbents, including situations to watch out for...

  • Mineral-Based & Clay-Based Absorbents

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: If this material is being used as a weapon, see ERG Table 1 - Initial Isolation and Protective Action Distances on the ERG Guide 153 datasheet for unassigned UN/NA numbers. Otherwise increase the immediate precautionary measure distance, in the downwind direction, as necessary.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Firefighting
Use protective clothing and respiratory protection. (EPA, 1998)
Non-Fire Response
Decontaminants include bleach slurry and hot soapy water. (EPA, 1998)
Protective Clothing
For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)
DuPont Tychem® Suit Fabrics
Tychem® Fabric Legend
QS = Tychem 2000 SFR
QC = Tychem 2000
SL = Tychem 4000
C3 = Tychem 5000
TF = Tychem 6000
TP = Tychem 6000 FR
RC = Tychem RESPONDER® CSM
TK = Tychem 10000
RF = Tychem 10000 FR
Testing Details
The fabric permeation data was generated for DuPont by a third party laboratory. Permeation data for industrial chemicals is obtained per ASTM F739. Normalized breakthrough times (the time at which the permeation rate exceeds 0.1 μg/cm2/min) are reported in minutes. All chemicals have been tested between approximately 20°C and 27°C unless otherwise stated. All chemicals have been tested at a concentration of greater than 95% unless otherwise stated. Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50% relative humidity per military standard MIL-STD-282. "Breakthrough time" for chemical warfare agents is defined as the time when the cumulative mass which permeated through the fabric exceeds the limit in MIL-STD-282 [either 1.25 or 4.0 μg/cm2].
A Caution from DuPont
This information is based upon technical data that DuPont believes to be reliable on the date issued. It is subject to revision as additional knowledge and experience are gained. The information reflects laboratory performance of fabrics, not complete garments, under controlled conditions. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk. It is the user's responsibility to determine the level of toxicity and the proper personal protective equipment needed. Anyone intending to use this information should first verify that the garment selected is suitable for the intended use. In many cases, seams and closures have shorter breakthrough times and higher permeation rates than the fabric. If fabric becomes torn,abraded or punctured, or if seams or closures fail, or if attached gloves, visors, etc. are damaged, end user should discontinue use of garment to avoid potential exposure to chemical. Since conditions of use are outside our control, DuPont makes no warranties, express or implied, including, without limitation, no warranties of merchantability or fitness for a particular use and assume no liability in connection with any use of this information. This information is not intended as a license to operate under or a recommendation to infringe any patent, trademark or technical information of DuPont or others covering any material or its use.
Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP RC TK RF
VX Nerve Agent, FINABEL 0.7.C 50782-69-9 Liquid >1400⁸ >1400⁸
VX Nerve Agent, MIL-STD-282 (10 g/m2) 50782-69-9 Liquid >480⁸ >480⁸ >480⁸ >480⁸ >480⁸
VX Nerve Agent, MIL-STD-282 (100 g/m2) 50782-69-9 Liquid >480⁸ >480⁸ >480⁸ >480⁸ >480⁸
> indicates greater than.
⁸ indicates actual breakthrough time; normalized breakthrough time is not available.

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

...Tychem® ThermoPro, Tychem® Reflector® and Tychem® TK styles 600T/601T (with aluminized outer suit) garments are designed and tested to help reduce burn injury during escape from a flash fire. Users of Tychem® ThermoPro, Tychem® Reflector® and Tychem® TK styles 600T/601T (with aluminized outer suit) garments should not knowingly enter an explosive environment. Tychem® garments with attached socks must be worn inside protective outer footwear and are not suitable as outer footwear. These attached socks do not have adequate durability or slip resistance to be worn as the outer foot covering.

(DuPont, 2022)

First Aid
Warning: Immediate decontamination of the smallest drop is essential. Death can occur 15 minutes after a fatal dose is absorbed.

Note: Phosphonothioic acid, methyl-, S-(2-(bis(l-methylethyl) amino)ethyl) O-ethyl ester is an extremely active cholinesterase inhibitor.

Signs and Symptoms of Phosphonothioic acid, methyl-, S-(2-(bis(l methylethyl)amino)ethyl) O-ethyl ester exposure: The first indication of exposure to phosphonothioic acid, methyl-, S-(2-(bis(l-methylethyl) amino) ethyl) O-ethyl ester may be a reaction at the point of contact: localized sweating, muscle twitching, and pinpoint eye pupils. Rhinorrhea (running nose), tightness of the chest with shortness of breath, and dimness of vision may be noted. In more severe exposure, headache, cramps, nausea, vomiting, involuntary defecation and urination, twitching, jerking, staggering, convulsions, drowsiness, coma, and respiratory arrest may be seen.

Emergency Life-Support Procedures: Acute exposure to phosphonothioic acid, methyl-, S-(2-(bis(l methylethyl)amino)ethyl) O-ethyl ester may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.

Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phosphonothioic acid, methyl-, S-(2-(bis(l- methylethyl)amino)ethyl) O-ethyl ester.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists. If breathing is labored, administer oxygen or other respiratory support.
4.Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to phosphonothioic acid, methyl-, S-(2- (bis(l-methylethyl)amino)ethyl) O-ethyl ester.
2. RUSH to a health care facility!
3. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists. If breathing is labored, administer oxygen or other respiratory support.
4. Remove and isolate contaminated clothing as soon as possible.
5. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
6. Wash exposed skin areas thoroughly with commercial household bleach and then flush with water. Avoid contacting the eyes or mouth with bleach.
7. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. DO NOT perform mouth-to-mouth resuscitation when facial contamination exists. If breathing is labored, administer oxygen or other respiratory support.
2. RUSH to a health care facility!
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. DO NOT induce vomiting or attempt to neutralize!
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. (EPA, 1998)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C11H26NO2PS
Flash Point: 318.2°F (EPA, 1998)
Lower Explosive Limit (LEL): data unavailable
Upper Explosive Limit (UEL): data unavailable
Autoignition Temperature: data unavailable
Melting Point: Freezing point below -60°F (EPA, 1998)
Vapor Pressure: 0.0007 mmHg at 77°F (EPA, 1998)
Vapor Density (Relative to Air): 9.2 (EPA, 1998)
Specific Gravity: 1.0083 at 77°F (EPA, 1998)
Boiling Point: 568°F at 760 mmHg decomposes (EPA, 1998)
Molecular Weight: 267.37 (EPA, 1998)
Water Solubility: data unavailable
Ionization Energy/Potential: data unavailable
IDLH: data unavailable

AEGLs (Acute Exposure Guideline Levels)

Final AEGLs for Agent VX (50782-69-9)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes 5.2e-05 ppm 0.00065 ppm 0.0027 ppm
30 minutes 3e-05 ppm 0.00038 ppm 0.0014 ppm
60 minutes 1.6e-05 ppm 0.00027 ppm 0.00091 ppm
4 hours 9.1e-06 ppm 0.00014 ppm 0.00048 ppm
8 hours 6.5e-06 ppm 9.5e-05 ppm 0.00035 ppm
(NAC/NRC, 2022)

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Agent VX; (Ethyl-S-dimethylaminoethyl methylphosphonothiolate) (50782-69-9) 1.6e-05 ppm 0.00027 ppm 0.00091 ppm
(DOE, 2018)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Phosphonothioic acid, methyl-, S-(2-(bis(1-methylethyl)amino)ethyl) O-ethyl ester 50782-69-9 100 pounds 100 pounds

(EPA List of Lists, 2022)

CISA Chemical Facility Anti-Terrorism Standards (CFATS)

RELEASE THEFT SABOTAGE
Chemical of Interest CAS Number Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
Min Conc STQ Security
Issue
VX; [o-Ethyl-S-2-diisopropylaminoethyl methyl phosphonothiolate] 50782-69-9 CUM 100 grams CW/CWP

(CISA, 2007)

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • A 4
  • ETHYL S-DIMETHYLAMINO- ETHYL METHYLPHOSPHONOTHIOLATE
  • ETHYL-S-DIISOPROPYLAMINOETHYL METHYLTHIOPHOSPHONATE
  • MPT
  • O-ETHYL S-(2-DIISOPROPYLAMINOETHYL) METHYLPHOSPHONOTHIOATE
  • O-ETHYL S-(2-DIISOPROPYLAMINOETHYL) METHYLTHIOPHOSPHONATE
  • O-ETHYL S-DIISOPROPYLAMINOETHYL METHYLPHOSPHONOTHIOATE
  • PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(BIS(1-METHYLETHYL
  • PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(BIS(1-METHYLETHYL)AMINO)ETHYL) O-ETHYL ESTER
  • PHOSPHONOTHIOIC ACID, METHYL-, S-(2-(DIISOPROPYLAMINO)ETHYL) O-ETHYL ESTER
  • S-(2-DIISOPROPYLAMINOETHYL) O-ETHYL METHYLPHOSPHONOTHIOLATE
  • S-2-DIISOPROPYLAMINOETHYL O-ETHYL METHYLPHOSPHONOTHIOATE
  • S-[2-(DIISOPROPYLAMINO)ETHYL] O-ETHYL METHYLPHOSPHONOTHIOLATE
  • TX 60
  • VX (CHEMICAL WARFARE AGENT)
  • VX AGENT
  • VX VAPOR

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