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N-HEXANE

3 - Flammable liquid
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The Chemical Identifier fields include common identification numbers, the NFPA diamond U.S. Department of Transportation hazard labels, and a general description of the chemical. The information in CAMEO Chemicals comes from a variety of data sources.
CAS Number UN/NA Number
  • 110-54-3   (N-HEXANE)
DOT Hazard Label USCG CHRIS Code
  • Flammable Liquid
NIOSH Pocket Guide International Chem Safety Card
n-Hexaneexternal link
NFPA 704
Diamond Hazard Value Description
3
   0
Blue Health
Red Flammability 3 Can be ignited under almost all ambient temperature conditions.
Yellow Instability 0 Normally stable, even under fire conditions.
White Special
(NFPA, 2010)
General Description
Clear colorless liquids with a petroleum-like odor. Flash points -9°F. Less dense than water and insoluble in water. Vapors heavier than air. Used as a solvent, paint thinner, and chemical reaction medium.

The Hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. The information in CAMEO Chemicals comes from a variety of data sources.
Reactivity Alerts
  • Highly Flammable
Air & Water Reactions
Highly flammable. Insoluble in water.
Fire Hazard
Behavior in Fire: Vapors may explode (USCG, 1999)
Health Hazard
INHALATION causes irritation of respiratory tract, cough, mild depression, cardiac arrhythmias. ASPIRATION causes severe lung irritation, coughing, pulmonary edema; excitement followed by depression. INGESTION causes nausea, vomiting, swelling of abdomen, headache, depression. (USCG, 1999)
Reactivity Profile
HEXANE may be sensitive to light. It may also be sensitive to prolonged exposure to heat. This compound can react vigorously with oxidizing materials. This would include compounds such as liquid chlorine, concentrated O2, sodium hypochlorite and calcium hypochlorite. It is also incompatible with dinitrogen tetraoxide. It will attack some forms of plastics, rubber and coatings. (NTP, 1992).
Belongs to the Following Reactive Group(s)
Potentially Incompatible Absorbents

No information available.

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.
Isolation and Evacuation
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.

LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2020)
Firefighting
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For mixtures containing alcohol or polar solvent, alcohol-resistant foam may be more effective.

SMALL FIRE: Dry chemical, CO2, water spray or regular foam.

LARGE FIRE: Water spray, fog or regular foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.

FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. For petroleum crude oil, do not spray water directly into a breached tank car. This can lead to a dangerous boil over. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2020)
Non-Fire Response
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.

LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2020)
Protective Clothing
Excerpt from NIOSH Pocket Guide for n-Hexaneexternal link:

Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.

Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.

Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.

Remove: WHEN WET (FLAMMABLE) - Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100°F).

Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2022)
DuPont Tychem® Suit Fabrics
Tychem® Fabric Legend
QS = Tychem 2000 SFR
QC = Tychem 2000
SL = Tychem 4000
C3 = Tychem 5000
TF = Tychem 6000
TP = Tychem 6000 FR
RC = Tychem RESPONDER® CSM
TK = Tychem 10000
RF = Tychem 10000 FR
Testing Details
The fabric permeation data was generated for DuPont by a third party laboratory. Permeation data for industrial chemicals is obtained per ASTM F739. Normalized breakthrough times (the time at which the permeation rate exceeds 0.1 μg/cm2/min) are reported in minutes. All chemicals have been tested between approximately 20°C and 27°C unless otherwise stated. All chemicals have been tested at a concentration of greater than 95% unless otherwise stated. Chemical warfare agents (Lewisite, Sarin, Soman, Sulfur Mustard, Tabun and VX Nerve Agent) have been tested at 22°C and 50% relative humidity per military standard MIL-STD-282. "Breakthrough time" for chemical warfare agents is defined as the time when the cumulative mass which permeated through the fabric exceeds the limit in MIL-STD-282 [either 1.25 or 4.0 μg/cm2].
A Caution from DuPont
This information is based upon technical data that DuPont believes to be reliable on the date issued. It is subject to revision as additional knowledge and experience are gained. The information reflects laboratory performance of fabrics, not complete garments, under controlled conditions. It is intended for informational use by persons having technical skill for evaluation under their specific end-use conditions, at their own discretion and risk. It is the user's responsibility to determine the level of toxicity and the proper personal protective equipment needed. Anyone intending to use this information should first verify that the garment selected is suitable for the intended use. In many cases, seams and closures have shorter breakthrough times and higher permeation rates than the fabric. If fabric becomes torn,abraded or punctured, or if seams or closures fail, or if attached gloves, visors, etc. are damaged, end user should discontinue use of garment to avoid potential exposure to chemical. Since conditions of use are outside our control, DuPont makes no warranties, express or implied, including, without limitation, no warranties of merchantability or fitness for a particular use and assume no liability in connection with any use of this information. This information is not intended as a license to operate under or a recommendation to infringe any patent, trademark or technical information of DuPont or others covering any material or its use.
Normalized Breakthrough Times (in Minutes)
Chemical CAS Number State QS QC SL C3 TF TP RC TK RF
Hexane, n- 110-54-3 Liquid imm imm >480 >480 >480 >480 >480 >480
> indicates greater than.
"imm" indicates immediate; having a normalized breakthrough time of 10 minutes or less.

Special Warning from DuPont: Tychem® and Tyvek® fabrics should not be used around heat, flames, sparks or in potentially flammable or explosive environments. Only...

...Tychem® ThermoPro, Tychem® Reflector® and Tychem® TK styles 600T/601T (with aluminized outer suit) garments are designed and tested to help reduce burn injury during escape from a flash fire. Users of Tychem® ThermoPro, Tychem® Reflector® and Tychem® TK styles 600T/601T (with aluminized outer suit) garments should not knowingly enter an explosive environment. Tychem® garments with attached socks must be worn inside protective outer footwear and are not suitable as outer footwear. These attached socks do not have adequate durability or slip resistance to be worn as the outer foot covering.

(DuPont, 2022)

First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds The information in CAMEO Chemicals comes from a variety of data sources.
Chemical Formula:
  • C6H14
Flash Point: -9.4°F (NTP, 1992)
Lower Explosive Limit (LEL): 1.2 % (NTP, 1992)
Upper Explosive Limit (UEL): 7.5 % (NTP, 1992)
Autoignition Temperature: 437°F (USCG, 1999)
Melting Point: -139°F (NTP, 1992)
Vapor Pressure: 120 mmHg at 68°F ; 180 mmHg at 77°F (NTP, 1992)
Vapor Density (Relative to Air): 2.97 (NTP, 1992)
Specific Gravity: 0.659 at 68°F (USCG, 1999)
Boiling Point: 156°F at 760 mmHg (NTP, 1992)
Molecular Weight: 86.18 (NTP, 1992)
Water Solubility: less than 1 mg/mL at 61.7°F (NTP, 1992)
Ionization Energy/Potential: 10.18 eV (NIOSH, 2022)
IDLH: 1100 ppm ; Based on 10% of the lower explosive limit. (NIOSH, 2022)

AEGLs (Acute Exposure Guideline Levels)

Final AEGLs for Hexane (110-54-3)
Exposure Period AEGL-1 AEGL-2 AEGL-3
10 minutes NR 4000 ppm 1-flame icon indicates value is 10-49% of LEL. Safety consideration against explosions must be taken into account. 12000 ppm 3-flame icon indicates value is 100% or more of LEL. Extreme safety consideration against explosions must be taken into account.
30 minutes NR 2900 ppm 1-flame icon indicates value is 10-49% of LEL. Safety consideration against explosions must be taken into account. 8600 ppm 2-flame icon indicates value is 50-99% of LEL. Extreme safety consideration against explosions must be taken into account.
60 minutes NR 2900 ppm 1-flame icon indicates value is 10-49% of LEL. Safety consideration against explosions must be taken into account. 8600 ppm 2-flame icon indicates value is 50-99% of LEL. Extreme safety consideration against explosions must be taken into account.
4 hours NR 2900 ppm 1-flame icon indicates value is 10-49% of LEL. Safety consideration against explosions must be taken into account. 8600 ppm 2-flame icon indicates value is 50-99% of LEL. Extreme safety consideration against explosions must be taken into account.
8 hours NR 2900 ppm 1-flame icon indicates value is 10-49% of LEL. Safety consideration against explosions must be taken into account. 8600 ppm 2-flame icon indicates value is 50-99% of LEL. Extreme safety consideration against explosions must be taken into account.
Lower Explosive Limit (LEL) = 11000 ppm
NR = Not recommended due to insufficient data
1-flame icon indicates value is 10-49% of LEL. Safety consideration against explosions must be taken into account.
2-flame icon indicates value is 50-99% of LEL. Extreme safety consideration against explosions must be taken into account.
3-flame icon indicates value is 100% or more of LEL. Extreme safety consideration against explosions must be taken into account.
(NAC/NRC, 2022)

ERPGs (Emergency Response Planning Guidelines)

No ERPG information available.

PACs (Protective Action Criteria)

Chemical PAC-1 PAC-2 PAC-3
Hexane (110-54-3) 260 ppm 2900 ppm 1-flame icon indicates value is 10-49% of LEL. 8600 ppm 2-flame icon indicates value is 50-99% of LEL. LEL = 11000 ppm
1-flame icon indicates value is 10-49% of LEL.
2-flame icon indicates value is 50-99% of LEL.
(DOE, 2018)

The Regulatory Information fields include information from the U.S. Environmental Protection Agency's Title III Consolidated List of Lists, the U.S. Cybersecurity and Infrastructure Security Agency's Chemical Facility Anti-Terrorism Standards, and the U.S. Occupational Safety and Health Administration's Process Safety Management of Highly Hazardous Chemicals Standard List (see more about these data sources).

EPA Consolidated List of Lists

Regulatory Name CAS Number/
313 Category Code
EPCRA 302
EHS TPQ
EPCRA 304
EHS RQ
CERCLA RQ EPCRA 313
TRI
RCRA
Code
CAA 112(r)
RMP TQ
Hexane 110-54-3 5000 pounds X
n-Hexane 110-54-3 5000 pounds 313

(EPA List of Lists, 2022)

CISA Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

OSHA Process Safety Management (PSM) Standard List

No regulatory information available.

This section provides a listing of alternate names for this chemical, including trade names and synonyms.
  • DIPROPYL
  • GETTYSOLVE-B
  • HEXANE
  • HEXANE (N)
  • HEXANES
  • HEXYL HYDRIDE
  • N-HEXANE
  • NCI-C60571
  • NORMAL HEXANE
  • NORMAL-HEXANE
  • SKELLYSOLVE B

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